Uncovering Driver DNA Methylation Events in Nonsmoking Early Stage Lung Adenocarcinoma

Table 1

Top 30 genes ranked by differential score in lung adenocarcinoma.

Gene symbol	Differential score	Number of samples in T-DM group	value
FAM107A [34]	16.301	20
SPARCL1 [35, 36]	14.920	20
TRPC6 [37]	14.649	11
CRYAB [38]	14.508	12
WFDC3	14.483	−14
EFEMP2 [39]	13.958	20
MX2 [40, 41]	13.895	−18
PLA2G4C [42]	13.870	−8
ST6GALNAC5 [43]	13.848	9
PLAT [44]	13.690	8
TCF21 [45]	13.664	22
SOX17 [46]	13.368	22
SH3GL2 [47]	13.300	5
MAMDC2 [18]	13.274	19
GCNT3 [48]	13.238	−14
MSR1 [49]	13.144	−16
PPP1R14D [50]	13.057	−12
COL5A2 [51]	13.045	19
PTPRH [52]	12.967	−16
HKDC1 [53]	12.961	−20
CDH13 [54]	12.932	−20
CFI [55]	12.932	5
ARL14	12.880	−12
MMP9 [56]	12.866	7
CELSR3	12.856	16
CDO1 [57]	12.846	22
AGR2 [58]	12.836	−22
S100P [59, 60]	12.828	−10
DOCK2 [61]	12.777	20
TNFRSF1B [62]	12.736	13

Bold: gene literature annotated to lung cancer.
−: Gene hypomethylated in samples.