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BioMed Research International
Volume 2016, Article ID 2174657, 5 pages
Research Article

Predominance of Abdominal Visceral Adipose Tissue Reflects the Presence of Aortic Valve Calcification

Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, Fukushima 960-1295, Japan

Received 6 August 2015; Revised 2 December 2015; Accepted 28 December 2015

Academic Editor: Ramazan Akdemir

Copyright © 2016 Masayoshi Oikawa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Aortic valve calcification (AVC) is a common feature of aging and is related to coronary artery disease. Although abdominal visceral adipose tissue (VAT) plays fundamental roles in coronary artery disease, the relationship between abdominal VAT and AVC is not fully understood. Methods. We investigated 259 patients who underwent cardiac and abdominal computed tomography (CT). AVC was defined as calcified lesion on the aortic valve by CT. %abdominal VAT was calculated as abdominal VAT area/total adipose tissue area. Results. AVC was detected in 75 patients, and these patients showed higher %abdominal VAT (44% versus 38%, ) compared to those without AVC. When the cutoff value of %abdominal VAT was set at 40.9%, the area under the curve to diagnose AVC was 0.626. Multivariable logistic regression analysis showed that age (OR 1.120, 95% CI 1.078–1.168, ), diabetes (OR 2.587, 95% CI 1.323–5.130, ), and %abdominal VAT (OR 1.032, 95% CI 1.003–1.065, ) were independent risk factors for AVC. The net reclassification improvement value for detecting AVC was increased when %abdominal VAT was added to the model: 0.5093 (95% CI 0.2489–0.7697, ). Conclusion. We determined that predominance of VAT is associated with AVC.