Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2016, Article ID 2350974, 10 pages
http://dx.doi.org/10.1155/2016/2350974
Review Article

The Role of Targeted Temperature Management in Adult Patients Resuscitated from Nonshockable Cardiac Arrests: An Updated Systematic Review and Meta-Analysis

1School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China
2Emergency Department, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
3Emergency Department, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China

Received 29 June 2016; Revised 4 September 2016; Accepted 27 September 2016

Academic Editor: Theodoros Xanthos

Copyright © 2016 Lijuan Song et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Routine targeted temperature management is recommended for comatose adult patients with return of spontaneous circulation after cardiac arrest. However, the role of targeted temperature management in patients resuscitated from nonshockable cardiac arrests remains uncertain. We conducted an updated systematic review and meta-analysis to evaluate the effects of targeted temperature management in this population. Medline, EMBASE, and Cochrane databases were systematically reviewed for studies published between January 2005 and March 2016, in which targeted temperature management was compared with standard care or normothermia for adult patients resuscitated from nonshockable cardiac arrests. A total of 25 trials that included 5715 patients were identified from 10985 relevant papers. Pooled data showed that targeted temperature management not only associated with improved short-term survival (RR = 1.42, 95% CI: 1.28–1.57) and neurological function (RR = 1.63, 95% CI: 1.39–1.91) but also associated with improved long-term survival (RR = 1.64, 95% CI: 1.27–2.12) and neurological recovery (RR = 1.42, 95% CI: 1.07–1.90) in observational cohort studies. However, more frequent infectious complications were reported in hypothermia-treated patients (RR = 1.46, 95% CI: 1.26–1.70) and the quality of the evidence ranged from moderate to very low.