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BioMed Research International
Volume 2016, Article ID 2384561, 10 pages
http://dx.doi.org/10.1155/2016/2384561
Research Article

Perilla Oil Supplementation Ameliorates High-Fat/High-Cholesterol Diet Induced Nonalcoholic Fatty Liver Disease in Rats via Enhanced Fecal Cholesterol and Bile Acid Excretion

1School of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan, Hubei 430023, China
2School of Medicine, Jianghan University, Wuhan, Hubei, China
3Department of Blood Transfusion, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Received 26 February 2016; Accepted 31 July 2016

Academic Editor: Lixin Zhu

Copyright © 2016 Ting Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Verbeek, D. Cassiman, M. Lannoo et al., “Treatment of non-alcoholic fatty liver disease: can we already face the epidemic?” Acta Gastro-Enterologica Belgica, vol. 76, no. 2, pp. 200–209, 2013. View at Google Scholar · View at Scopus
  2. J.-G. Fan and G. C. Farrell, “Epidemiology of non-alcoholic fatty liver disease in China,” Journal of Hepatology, vol. 50, no. 1, pp. 204–210, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. G. C. Farrell, V. W.-S. Wong, and S. Chitturi, “NAFLD in Asia—as common and important as in the West,” Nature Reviews Gastroenterology and Hepatology, vol. 10, no. 5, pp. 307–318, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Gariani, J. Philippe, and F. R. Jornayvaz, “Non-alcoholic fatty liver disease and insulin resistance: from bench to bedside,” Diabetes and Metabolism, vol. 39, no. 1, pp. 16–26, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. H. C. Masuoka and N. Chalasani, “Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals,” Annals of the New York Academy of Sciences, vol. 1281, no. 1, pp. 106–122, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. A. J. McCullough, “Pathophysiology of nonalcoholic steatohepatitis,” Journal of Clinical Gastroenterology, vol. 40, no. 1, pp. S17–S29, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Te Sligte, I. Bourass, J. P. Sels, A. Driessen, R. W. Stockbrugger, and G. H. Koek, “Non-alcoholic steatohepatitis: review of a growing medical problem,” European Journal of Internal Medicine, vol. 15, no. 1, pp. 10–21, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. G. Musso, R. Gambino, G. Pacini, F. De Michieli, and M. Cassader, “Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver,” American Journal of Clinical Nutrition, vol. 89, no. 2, pp. 558–567, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Tomita, T. Teratani, H. Yokoyama et al., “Plasma free myristic acid proportion is a predictor of nonalcoholic steatohepatitis,” Digestive Diseases and Sciences, vol. 56, no. 10, pp. 3045–3052, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Lomonaco, C. Ortiz-Lopez, B. Orsak et al., “Role of ethnicity in overweight and obese patients with nonalcoholic steatohepatitis,” Hepatology, vol. 54, no. 3, pp. 837–845, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Musso, R. Gambino, F. De Michieli et al., “Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis,” Hepatology, vol. 37, no. 4, pp. 909–916, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. C. L. Gentile and M. J. Pagliassotti, “The role of fatty acids in the development and progression of nonalcoholic fatty liver disease,” Journal of Nutritional Biochemistry, vol. 19, no. 9, pp. 567–576, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Musso, R. Gambino, and M. Cassader, “Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis,” Progress in Lipid Research, vol. 52, no. 1, pp. 175–191, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. H.-K. Min, A. Kapoor, M. Fuchs et al., “Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease,” Cell Metabolism, vol. 15, no. 5, pp. 665–674, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Simonen, A. Kotronen, M. Hallikainen et al., “Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity,” Journal of Hepatology, vol. 54, no. 1, pp. 153–159, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. G. N. Ioannou, “The role of cholesterol in the pathogenesis of NASH,” Trends in Endocrinology and Metabolism, vol. 27, no. 2, pp. 84–95, 2016. View at Publisher · View at Google Scholar · View at Scopus
  17. V. Bieghs, S. M. A. Walenbergh, T. Hendrikx et al., “Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation,” Liver International, vol. 33, no. 7, pp. 1056–1061, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. V. Bieghs, T. Hendrikx, P. J. Van Gorp et al., “The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice,” Gastroenterology, vol. 144, no. 1, pp. 167.e1–178.e1, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. K. Tomita, T. Teratani, T. Suzuki et al., “Acyl-CoA: cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells,” Journal of Hepatology, vol. 61, no. 1, pp. 98–106, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Araya, R. Rodrigo, L. A. Videla et al., “Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease,” Clinical Science, vol. 106, no. 6, pp. 635–643, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. J. P. Allard, E. Aghdassi, S. Mohammed et al., “Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): a cross-sectional study,” Journal of Hepatology, vol. 48, no. 2, pp. 300–307, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. A. M. El-Badry, R. Graf, and P.-A. Clavien, “Omega 3—Omega 6: what is right for the liver?” Journal of Hepatology, vol. 47, no. 5, pp. 718–725, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. J. T. Brenna, “Efficiency of conversion of alpha-linolenic acid to long chain n-3 fatty acids in man,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 5, no. 2, pp. 127–132, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. F. Yuan, H. Wang, Y. Tian et al., “Fish oil alleviated high-fat diet-induced non-alcoholic fatty liver disease via regulating hepatic lipids metabolism and metaflammation: a transcriptomic study,” Lipids in Health and Disease, vol. 15, article 20, 2016. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Modica, S. Murzilli, and A. Moschetta, “Characterizing bile acid and lipid metabolism in the liver and gastrointestinal tract of mice,” Current Protocols in Mouse Biology, vol. 1, no. 2, pp. 289–321, 2011. View at Google Scholar
  26. D. E. Kleiner, E. M. Brunt, M. Van Natta et al., “Design and validation of a histological scoring system for nonalcoholic fatty liver disease,” Hepatology, vol. 41, no. 6, pp. 1313–1321, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. Q. Long, D. C. Jeffares, Q. Zhang et al., “PoolHap: inferring haplotype frequencies from pooled samples by next generation sequencing,” PLoS ONE, vol. 6, no. 1, Article ID e15292, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Konczal, P. Koteja, M. T. Stuglik, J. Radwan, and W. Babik, “Accuracy of allele frequency estimation using pooled RNA-Seq,” Molecular Ecology Resources, vol. 14, no. 2, pp. 381–392, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. D. W. Huang, B. T. Sherman, and R. A. Lempicki, “Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources,” Nature Protocols, vol. 4, no. 1, pp. 44–57, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. B. A. Merrick, D. P. Phadke, S. S. Auerbach et al., “RNA-Seq profiling reveals novel hepatic gene expression pattern in aflatoxin B1 treated rats,” PLoS ONE, vol. 8, no. 4, Article ID e61768, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. T. B. Langston, P. B. Hylemon, and W. M. Grogan, “Over-expression of hepatic neutral cytosolic cholesteryl ester hydrolase in mice increases free cholesterol and reduces expression of HMG-CoAR, CYP27, and CYP7A1,” Lipids, vol. 40, no. 1, pp. 31–38, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. Á. Baldán, D. D. Bojanic, and P. A. Edwards, “The ABCs of sterol transport,” Journal of Lipid Research, vol. 50, pp. S80–S85, 2009. View at Publisher · View at Google Scholar
  33. M. C. Cave, H. B. Clair, J. E. Hardesty et al., “Nuclear receptors and nonalcoholic fatty liver disease,” Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, vol. 1859, no. 9, pp. 1083–1099, 2016. View at Publisher · View at Google Scholar
  34. S. B. Ahn, K. Jang, D. W. Jun, B. H. Lee, and K. J. Shin, “Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease,” Digestive Diseases and Sciences, vol. 59, no. 12, pp. 2975–2982, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. R. M. Evans and D. J. Mangelsdorf, “Nuclear receptors, RXR, and the big bang,” Cell, vol. 157, no. 1, pp. 255–266, 2014. View at Publisher · View at Google Scholar · View at Scopus
  36. T. Inagaki, M. Choi, A. Moschetta et al., “Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis,” Cell Metabolism, vol. 2, no. 4, pp. 217–225, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. J. A. Alvarez and A. Ashraf, “Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis,” International Journal of Endocrinology, vol. 2010, Article ID 351385, 18 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. S. Zúñiga, D. Firrincieli, C. Housset, and N. Chignard, “Vitamin D and the vitamin D receptor in liver pathophysiology,” Clinics and Research in Hepatology and Gastroenterology, vol. 35, no. 4, pp. 295–302, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. R. M. Kwok, D. M. Torres, and S. A. Harrison, “Vitamin D and nonalcoholic fatty liver disease (NAFLD): is it more than just an association?” Hepatology, vol. 58, no. 3, pp. 1166–1174, 2013. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Bozic, C. Guzmán, M. Benet et al., “Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis,” Journal of Hepatology, 2016. View at Publisher · View at Google Scholar