Research Article

Neurotrophin, p75, and Trk Signaling Module in the Developing Nervous System of the Marine Annelid Platynereis dumerilii

Figure 3

Phylogenetic analysis of annelid Trk, p75, and NT. (a) Trk; (b) p75; (c) NT. Statistical support per node is shown. Outgroups or midbranching was used to root the trees; Platynereis sequences are indicated with dotted black squares. ML bootstrap values are indicated for 100 replicates. For comparison, different members of the RTK (a) and TNFRSF (b) superfamily are shown (details in the text). In (a) only the tyrosine kinase domain is used for the analysis, and in (c) only the mature protein (Cys-Knot) is used, i: invertebrate, and v: vertebrates. The species used for comparison are indicated as in Figures 1 and 2. In addition, Sp: Strongylocentrotus purpuratus, GalG: Gallus gallus, Lymnaea: Lymnaea stagnalis, Aply: Aplysia, Dm: Drosophila melanogaster, Hr: Helobdella robusta, and Nv: Nematostella vectensis. TickIs: Ixodes scapularis tick, TickRm: Rhipicephalus microplus tick, and Dap or Dpulex: Daphnia pulex.
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