Figure 1: Summary of methods for DNA methylation and histone modification analysis. Different approaches, depending on whether global, locus-specific, or genome-wide analyses, are performed. HPCE: high-performance capillary electrophoresis; HPLC: high-performance liquid chromatography; MS: mass spectrometry; BP: bisulfite pyrosequencing; MSP: methylation-specific PCR; BS: bisulfite sequencing; MeDIP-seq: methylated DNA immunoprecipitation sequencing; RRBS: reduced representation bisulfite sequencing; WGBS: whole genome bisulfite sequencing; RP-HPLC: reversed-phase high-performance liquid chromatography (RP-HPLC); ChIP: chromatin immunoprecipitation; ISH-PLA: in situ hybridization and proximity ligation assay.