Evaluation of Neuroprotective Effect of Thymoquinone Nanoformulation in the Rodent Cerebral Ischemia-Reperfusion Model

Table 2

Effect of thymoquinone loaded PLGA nanoparticles on locomotor activity, grip strength, and cerebral infract volume in the MCAO rats.

Groups	Treatment	Locomotor activity; (count/5 min)	Grip strength; (Kg/unit)	Infarct volume (mm^3)^#
1	Sham control	21.62 ± 0.312	0.68 ± 0.053	—
2	MCAO control	3.54 ± 0.021	0.12 ± 0.03	76.28 ± 0.112
3	MCAO + TQ; PLGA NPs (i.n.)	16.89 ± 0.218	0.36 ± 0.087	38.34 ± 0.123
4	MCAO + TQ; solution (i.n.)	15.12 ± 0.093	0.19 ± 0.101	45.19 ± 0.091
5	MCAO + TQ; solution (oral)	9.23 ± 0.101	0.23 ± 0.214	44.78 ± 0.153

The intranasal delivery of TQ-PLGA nanoparticles led to significant increase in the locomotor activity and grip strength and decrease in ischemia infarct volume in the MCAO rats when compared to TQ solution delivered by intranasal or oral route alone. ( = 6); data represent mean ± SEM; versus sham control;    versus MCAO control; and   versus MCAO control.