Dehydroabietic Acid Derivative QC4 Induces Gastric Cancer Cell Death via Oncosis and Apoptosis

Figure 2

QC4 induced cell death in gastric cancer cells. (a) SGC-7901 cells were incubated with QC4 of indicated concentrations for indicated time, QC4 impaired cell viability time- and dose-dependently. (b) MGC80-3 cells were incubated with QC4 of indicated concentrations for indicated time, QC4 impaired cell viability time- and dose-dependently. (c) Flow cytometric analysis of SGC-7901 and MGC80-3 after QC4 administration at indicated concentrations for 24 h. (d) Morphological change of SGC-7901 and MGC80-3 after QC4 administration at 10 μg/mL for indicated time ( for QC4 treatment compared with the DMSO treated control group for 12 h; for QC4 treatment compared with the DMSO treated control group for 24 h; for QC4 treatment compared with the DMSO treated control group for 48 h).

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