Research Article
Dehydroabietic Acid Derivative QC4 Induces Gastric Cancer Cell Death via Oncosis and Apoptosis
Figure 5
ATP depletion, mitochondrial membrane potential decrease, ROS generation, and cytosolic free Ca2+ elevation were observed in oncotic gastric cancer cells. ATP (a) and Δψm (b) level generally decreased in 10 μg/mL QC4-treated SGC-7901 and MGC80-3 cells time-dependently. ROS accumulation (c) and cytosolic free Ca2+ concentrations (d) were detected after 10 μg/mL QC4 administration for indicated time in SGC-7901 and MGC80-3 cells ( for QC4 treatment compared with the DMSO treated control group in SGC-7901; for QC4 treatment compared with the DMSO treated control group in MGC80-3).
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