Research Article
Herpes Simplex Virus Type 1 and Type 2 Infection Increases Atherosclerosis Risk: Evidence Based on a Meta-Analysis
Table 2
Characteristics of literatures included in the meta-analysis concerning HSV-2.
| First author | Year | Country | Region | Disease type | Test method | Male proportion | Age | Sample size | Case size | Control size | HSV-2 (+) | HSV-2 (−) | HSV-2 (+) | HSV-2 (−) |
| Jafarzadeh [24] | 2011 | Iran | Asian | Myocardial ischemia | ELISA | 59% | 54 | 180 | 34 | 86 | 17 | 43 | Georges [28] | 2003 | Germany | European | Myocardial ischemia | ELISA | 73% | 62 | 1324 | 139 | 852 | 27 | 306 | Lindberg [29] | 1997 | Sweden | European | Carotid artery disease | SPRIA | — | — | 534 | 64 | 203 | 66 | 201 | Guan [15] | 2012 | China | Asian | Myocardial ischemia | ELISA | 62% | 56 | 252 | 56 | 46 | 57 | 93 | Zhu [30] | 2000 | America | American | Myocardial ischemia | ELISA | 63% | 57 | 233 | 84 | 74 | 32 | 43 | Kis [14] | 2007 | Hungary | European | Stroke | ELISA | 58% | 52 | 111 | 23 | 36 | 14 | 38 | Adam [31] | 1987 | America | American | Mixed AS lesions | SPRIA | 100% | 58 | 226 | 30 | 83 | 31 | 82 |
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HSV-2: herpes simplex virus type 2; ELISA: enzyme-linked immunosorbent assay; SPRIA: solid-phase radioimmunoassay; AS: atherosclerosis.
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