Herpes Simplex Virus Type 1 and Type 2 Infection Increases Atherosclerosis Risk: Evidence Based on a Meta-Analysis

Table 2

Characteristics of literatures included in the meta-analysis concerning HSV-2.

First author	Year	Country	Region	Disease type	Test method	Male proportion	Age	Sample size	Case size		Control size
									HSV-2 (+)	HSV-2 (−)	HSV-2 (+)	HSV-2 (−)
Jafarzadeh [24]	2011	Iran	Asian	Myocardial ischemia	ELISA	59%	54	180	34	86	17	43
Georges [28]	2003	Germany	European	Myocardial ischemia	ELISA	73%	62	1324	139	852	27	306
Lindberg [29]	1997	Sweden	European	Carotid artery disease	SPRIA	—	—	534	64	203	66	201
Guan [15]	2012	China	Asian	Myocardial ischemia	ELISA	62%	56	252	56	46	57	93
Zhu [30]	2000	America	American	Myocardial ischemia	ELISA	63%	57	233	84	74	32	43
Kis [14]	2007	Hungary	European	Stroke	ELISA	58%	52	111	23	36	14	38
Adam [31]	1987	America	American	Mixed AS lesions	SPRIA	100%	58	226	30	83	31	82

HSV-2: herpes simplex virus type 2; ELISA: enzyme-linked immunosorbent assay; SPRIA: solid-phase radioimmunoassay; AS: atherosclerosis.