Research Article

DASAF: An R Package for Deep Sequencing-Based Detection of Fetal Autosomal Abnormalities from Maternal Cell-Free DNA

Table 2

Execution time (in seconds) to detect chromosomal abnormalities using different methods.

12 M reads20 M reads40 M reads

Standard -score (STDZ) method112
GC Correction -score (GCCZ) method3126291,156
Internal reference -score (IRZ) method111
Subchromosome abnormality -score (SCAZ) method2,0742,1052,278

The computing platform is a Linux system with 16 threads (0.8 GHZ for each) and RAM of 64 GB. Execution time was averaged over five repetitive runs.