Differences in Rhodococcus equi Infections Based on Immune Status and Antibiotic Susceptibility of Clinical Isolates in a Case Series of 12 Patients and Cases in the Literature
Table 1
Demographic and clinical characteristics of R. equi infection at the University of Kentucky.
Year
Patient data
Clinical data
Case/age/gender
Occupational/environmental exposure to livestock
Specimen source
Clinical symptoms
Immune status
CD4 (%)
Viral load copies/mL
ART
Radiography
Treatment duration (months)
Surgery
Relapse/outcome
2001
1/40/m
Unknown
Sputum, blood
Fever, cough, nausea
HIV
27 (6)
56784
No
RUL infiltrate with cavitation and LUL infiltrate
3
No
Cured
2001
2/32/m
Unknown
Sputum, blood
Fever, nausea, weight loss
HIV
43 (4)
<400
Yes
LUL and LLL pneumonia
12
No
Relapsed†/expired
2003
3/33/m
Lawn care worker
Sputum
Fever, cough
HIV
60 (8)
257927
No
LUL cavitary lesion
9
No
Cured
2009
4/40/m
Unknown
Sputum
Cough, dyspnea
HIV
7 (3)
354000
No
Right lung infiltrate
36
No
Cured
2010
5/37/m
Horses
Sputum
Cough, dyspnea
HIV
59 (22)
276000
No
LLL cavitary lesion
24
No
Cured
2013
6/48/m
Horses, donkey
Blood pericardial fluid
Fever, cough, dyspnea
HIV
10 (5)
143000
No
Multiple bilateral nodular lesions
12
Pericardial drain
Cured
2008
7/62/m
Unknown
Sputum
Anorexia, dyspnea, nausea
Lung tx
NA
NA
No
Right pleural effusion
7
Pericardial drain
Cured
2012
8/53/m
Cattle, pigs
Blood
Fever, cough, dyspnea
Renal tx
NA
NA
No
RUL dense consolidation
15
No
Cured
2003
9/25/f
Motor vehicle accident with soil debris
Tissue
Left foot wound
NA
NA
NA
No
NA
3 weeks
Amputation
Cured
2005
10/53/m
Unknown
Sputum
Fever, cough, dyspnea, weight loss
NA
NA
NA
No
RUL cavitary lesion
Unknown
No
Expired‡
2007
11/79/f
Unknown
Blood
Fever
NA
NA
NA
No
LUL mass lesion, bilateral infiltrates
Unknown
Central line removed
Expired
2011
12/42/m
Unknown
Tissue
Right great toe wound
NA
NA
NA
No
NA
1
Amputation
Cured
HIV: human immune deficiency virus; tx: transplant; ART: antiretroviral therapy; RUL: right upper lobe; LUL: left upper lobe; LLL: left lower lobe; NA: not applicable. †R. equi bacteremia recurred after 9 months and the patient expired. ‡Lost to follow-up and expiredafter 15 months from unknown causes. Lost to follow-up and expired after 6 months from unknown causes.
