Comparative Evaluation of Anthelmintic Activity of Edible and Ornamental Pomegranate Ethanolic Extracts against Schistosoma mansoni

Table 1

In vitro effects of leaves and stem bark ethanolic extracts of edible and ornamental pomegranate on adult worms of S. mansoni after 12 h incubation period.

Group	Conc (µg/mL)	Incubation period (h)	Number of separated worms (%)	% of worm mortality	% of worms with tegumental alteration
					Partial	Extensive
SEP	500	2	95	90	—	—
		4	99	100	10	90
		6	100	100	—	—
		12	100	100	—	—
	300	2	87	80	—	—
		4	99	99	—	—
		6	99	100	30	70
		12	100	100	—	—
	100	2	71	60	—	—
		4	80	65	—	—
		6	95	90	—	—
		12	100	100	50	50
LEP	500	2	80	0	—	—
		4	85	45	—	—
		6	99	100	20	80
		12	100	100	—	—
	300	2	75	0	—	—
		4	85	70	—	—
		6	99	90	—	—
		12	100	100	15	85
	100	2	65	0	—	—
		4	80	0	—	—
		6	95	90	—	—
		12	100	100	60	40
LOP	500	2	40	0	—	—
		4	75	25	—	—
		6	85	100	20	80
		12	100	100	—	—
	300	2	30	0	—	—
		4	65	12	—	—
		6	75	34	—	—
		12	100	100	50	50
	100	2	20	0	—	—
		4	55	0	—	—
		6	70	0	—	—
		12	100	98	70	30
SOP	500	2	20	10	—	—
		4	60	45	—	—
		6	76	100	30	70
		12	100	100	—	—
	300	2	18	0	—	—
		4	60	0	—	—
		6	70	90	—	—
		12	100	100	85	15
	100	2	15	0	—	—
		4	55	0	—	—
		6	70	90	—	—
		12	100	100	90	10
PZQ	10	2	95	95	—	—
		4	100	100	25	75
Control −ve		2	0	0	—	—
		4	60	0	—	—
		6	70	10	—	—
		12	100	100	0	0

Incubation period: 12 h; control –ve in RPMI-1640 and medium with 3% tween 80 in 0.9% saline.