The Expression of NOX4 in Smooth Muscles of Small Airway Correlates with the Disease Severity of COPD

Figure 7

Correlation of the expression of NOX4 and ASM mass, pulmonary function, or ASM cell proliferation in COPD lungs. (a) Correlation between the expression of NOX4 and the WA% in small airway (; ). (b) Correlation between the expression of NOX4 and WT% in small airway (; ). (c) Correlation between the expression of NOX4 and pulmonary function index FEV1% pred (; ). (d) Correlation between the expression of NOX4 and pulmonary function index FEV1/FVC% (; ). (e) Correlation between the expression of laminin and NOX4 in ASM of small airway in indicated groups as determined by AOD values (; ). (f) Correlation between expression of NOX4 and PCNA as determined by AOD values (; ). The data showed a positive association of NOX4 level with ASM mass and proliferative capacity and a negative correlation with the pulmonary function. Spearman’s correlation coefficient and values are as indicated.

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