BioMed Research International / 2016 / Article / Tab 3 / Review Article
Prediction and Prevention of Acute Kidney Injury after Cardiac Surgery Table 3 Meta-analyses regarding pharmacologic renal protection for preventing acute kidney injury after cardiac surgery.
Agent Author/ Study type (RCT/ Outcome Patients (Drug/control, Pooled effect size (OR, 95% CI) Dopamine Zacharias et al. 2013 [79 ] 10 AKI 541 1.36 (0.44, 4.23) Not reported Not reported Fenoldopam Zangrillo et al. 2012 [81 ] 5 (5/0) AKI 202/207 0.41 (0.23, 0.74) 0.003 0% Fenoldopam Zangrillo et al. 2012 [81 ] 4 (4/0) RRT 183/188 0.67 (0.10, 4.48) 0.68 62% Statin Liakopoulos et al. 2008 [100 ] 5 (2/3) AKI 4236/2172 0.78 (0.46, 1.31) 0.34 58.3% Sodium bicarbonate Bailey et al. 2015 [89 ] 3 (3/0) 877 1.11 (0.77, 1.60) 0.45 Not reported Sodium bicarbonate Tie et al. 2014 [91 ] 5 (5/0) AKI 1079 0.99 (0.78, 1.24) 0.911 56.1% Mannitol Yang et al. 2014 [101 ] 4 (4/0) 94/93 −2.35 (−7.46, 2.75) 0.37 0% N-acetylcysteine Ho and Morgan 2009 [94 ] 10 RRT 485/487 1.04 (0.45, 2.37) 0.9 3.3% N-acetylcysteine Patel et al. 2011 [97 ] 4 (4/0) AKI 453/450 0.86 (0.66, 1.13) 0.29 0% N-acetylcysteine Patel et al. 2011 [97 ] 7 (7/0) RRT 503/499 0.98 (0.50, 1.92) 0.96 5% Atrial natriuretic peptide Patel et al. 2011 [97 ] 1 (1/0) AKI 251/253 0.35 (0.23, 0.76) 0.005 One study Atrial natriuretic peptide Patel et al. 2011 [97 ] 5 (5/0) RRT 427/426 0.24 (0.10, 0.56) 0.001 0% Brain natriuretic peptide Patel et al. 2011 [97 ] 2 (2/0) AKI 186/187 0.40 (0.21, 0.76) 0.005 40% Brain natriuretic peptide Patel et al. 2011 [97 ] 2 (2/0) RRT 64/69 0.80 (0.18, 3.64) 0.78 0% Steroids adults Scrascia et al. 2014 [99 ] 7 (7/0) AKI 291/289 1.13 (0.53, 2.43) Not reported 18.3% MECC Scrascia et al. 2014 [99 ] 6 (6/0) AKI 391/427 0.47 (0.18, 1.25) Not reported 0% Leukofiltration Scrascia et al. 2014 [99 ] 4 (4/0) AKI 157/157 0.18 (0.05, 0.64) Not reported 0%
AKI: acute kidney injury; RRT: renal replacement therapy.† Change of serum creatinine concentration.
