Conditioning with Fludarabine-Busulfan versus Busulfan-Cyclophosphamide Is Associated with Lower aGVHD and Higher Survival but More Extensive and Long Standing Bone Marrow Damage

Figure 3

Pathologic changes of aGVHD and chimerism analysis. (a) Pathologic changes of liver, spleen, intestine, and skin on day +14 after transplantation. (b) Pathologic scores for liver, spleen, intestine, and skin on day +14 after transplantation. (c) Bone marrow and spleen chimerism of allogeneic recipients on day +14 after transplantation. Group A: normal BALB/c in the same condition. Group E: BALB/c conditioned with Bu (100 mg/kg)-Cy (200 mg/kg) and transplanted with bone marrow cells, spleen cells from C57BL/6. Group H: BALB/c conditioned with Flu (500 mg/kg)-Bu (100 mg/kg) and transplanted with bone marrow cells, spleen cells from C57BL/6. All data are presented as mean ± s.e. for 3–7 animals in each group per time point. ; NS, not significant, .

(a)

(b)

(c)