The Circadian NAD⁺ Metabolism: Impact on Chromatin Remodeling and Aging

Figure 2

Circadian NAD⁺ metabolism modifies chromatin properties with a 24-hour rhythm. Circadian NAD⁺ metabolism controls histone modifications through acetylation and methylation processes, therefore regulating precise circadian gene expression. NAD⁺ with black arrow represents high NAD⁺ amount and NAD⁺ with gray arrow signifies low NAD⁺ amount.