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BioMed Research International
Volume 2016, Article ID 3272530, 6 pages
http://dx.doi.org/10.1155/2016/3272530
Research Article

Comparison of TIVA and Desflurane Added to a Subanaesthetic Dose of Propofol in Patients Undergoing Coronary Artery Bypass Surgery: Evaluation of Haemodynamic and Stress Hormone Changes

1Department of Anesthesiology, Erzincan University, 24030 Erzincan, Turkey
2Department of Anesthesiology, Göztepe Training and Research Hospital, 34722 Istanbul, Turkey
3Department of Cardiovascular Surgery, Erzincan University, 24030 Erzincan, Turkey
4Department of Cardiovascular Surgery, Kartal Koşuyolu High Specialization Training and Research Hospital, 34865 Istanbul, Turkey
5Department of Biochemistry, Erzincan University, 24030 Erzincan, Turkey
6Department of Internal Medicine, Division of Nephrology, Necmettin Erbakan University, Meram School of Medicine, 42080 Konya, Turkey
7Department of Anesthesiology, Kartal Koşuyolu High Specialization Training and Research Hospital, 34865 Istanbul, Turkey
8Department of Internal Medicine, Şişli Etfal Training and Research Hospital, 34363 Istanbul, Turkey

Received 29 January 2016; Revised 2 June 2016; Accepted 7 June 2016

Academic Editor: Theodoros Xanthos

Copyright © 2016 Didem Onk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Increased levels of stress hormones are associated with mortality in patients undergoing coronary artery bypass grafting (CABG). Aim. To compare total intravenous anaesthesia (TIVA) and desflurane added to a subanaesthetic dose of propofol. Material and Methods. Fifty patients were enrolled in this study. Fentanyl (3–5 mcg/kg/h) was started in both groups. Patients were divided into two groups. The PD group () received 1 minimum alveolar concentration (MAC) desflurane anaesthesia in addition to propofol infusion (2-3 mg/kg/h), while P group () received propofol infusion (5-6 mg/kg/h) only. Biochemical data, cortisol, and insulin levels were measured preoperatively (T0), after initiation of CPB but before cross-clamping the aorta (T1), after removal of the cross-clamp (T2), and at the 24th postoperative hour (T3). Results. Systolic, diastolic, and mean arterial pressure levels were significantly higher in PD group than those in P group in T1 and T2 measurements (). CK-MB showed a significant decrease in group P (). When we compared both groups, cortisol levels were significantly higher in PD group than P group (). Conclusion. Stress and haemodynamic responses were better controlled using TIVA than desflurane inhalation added to a subanaesthetic dose of propofol in patients undergoing CABG.