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BioMed Research International
Volume 2016, Article ID 3524842, 10 pages
http://dx.doi.org/10.1155/2016/3524842
Research Article

Complement Factor 3 Could Be an Independent Risk Factor for Mortality in Patients with HBV Related Acute-on-Chronic Liver Failure

1Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China
2Guangdong Provincial Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China
3Department of Ultrasound, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China
4Department of Infectious Diseases, Foshan Hospital of Sun Yat-Sen University, Foshan 528000, China
5Key Laboratory of Tropical Disease Control, Sun Yat-Sen University, Ministry of Education, Guangzhou 510630, China

Received 3 December 2015; Revised 8 March 2016; Accepted 20 March 2016

Academic Editor: Paul M. Tulkens

Copyright © 2016 Geng-lin Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Jalan, P. Gines, J. C. Olson et al., “Acute-on chronic liver failure,” Journal of Hepatology, vol. 57, no. 6, pp. 1336–1348, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. F.-S. Wang and Z. Zhang, “How can acute-on-chronic liver failure be accurately identified?” Nature Reviews Gastroenterology & Hepatology, vol. 10, no. 7, pp. 390–391, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. H. E. Wasmuth, D. Kunz, E. Yagmur et al., “Patients with acute on chronic liver failure display ‘sepsis-like’ immune paralysis,” Journal of Hepatology, vol. 42, no. 2, pp. 195–201, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. X. Qin and B. Gao, “The complement system in liver diseases,” Cellular & Molecular Immunology, vol. 3, no. 5, pp. 333–340, 2006. View at Google Scholar · View at Scopus
  5. P. Gasque, “Complement: a unique innate immune sensor for danger signals,” Molecular Immunology, vol. 41, no. 11, pp. 1089–1098, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. M. J. Walport, “Complement. Second of two parts,” The New England Journal of Medicine, vol. 344, no. 15, pp. 1140–1144, 2001. View at Publisher · View at Google Scholar
  7. P. A. Ward, “The dark side of C5a in sepsis,” Nature Reviews Immunology, vol. 4, no. 2, pp. 133–142, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Clark, A. Weymann, E. Hartman et al., “Evidence for non-traditional activation of complement factor C3 during murine liver regeneration,” Molecular Immunology, vol. 45, no. 11, pp. 3125–3132, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Hillebrandt, H. E. Wasmuth, R. Weiskirchen et al., “Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans,” Nature Genetics, vol. 37, no. 8, pp. 835–843, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. S. He, C. Atkinson, F. Qiao, K. Cianflone, X. Chen, and S. Tomlinson, “A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration in mice,” Journal of Clinical Investigation, vol. 119, no. 8, pp. 2304–2316, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. B. Gao, E. Seki, D. A. Brenner et al., “Innate immunity in alcoholic liver disease,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 300, no. 4, pp. G516–G525, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. S. S. Rensen, Y. Slaats, A. Driessen et al., “Activation of the complement system in human nonalcoholic fatty liver disease,” Hepatology, vol. 50, no. 6, pp. 1809–1817, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. B. Mazumdar, H. Kim, K. Meyer et al., “Hepatitis C virus proteins inhibit C3 complement production,” Journal of Virology, vol. 86, no. 4, pp. 2221–2228, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Sun, Y. Guo, G. Zhao et al., “Complement and the alternative pathway play an important role in LPS/D-GalN-induced fulminant hepatic failure,” PloS ONE, vol. 6, no. 11, Article ID e26838, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Farci, G. Diaz, Z. Chen et al., “B cell gene signature with massive intrahepatic production of antibodies to hepatitis B core antigen in hepatitis B virus-associated acute liver failure,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 19, pp. 8766–8771, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. G.-L. Zhang, D.-Y. Xie, B.-L. Lin et al., “Imbalance of interleukin-17-producing CD4 T cells/regulatory T cells axis occurs in remission stage of patients with hepatitis B virus-related acute-on-chronic liver failure,” Journal of Gastroenterology and Hepatology, vol. 28, no. 3, pp. 513–521, 2013. View at Publisher · View at Google Scholar
  17. L. Peng, D.-Y. Xie, B.-L. Lin et al., “Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: short-term and long-term outcomes,” Hepatology, vol. 54, no. 3, pp. 820–828, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. A. E. Ruf, W. K. Kremers, L. L. Chavez, V. I. Descalzi, L. G. Podesta, and F. G. Villamil, “Addition of serum sodium into the MELD score predicts waiting list mortality better than MELD alone,” Liver Transplantation, vol. 11, no. 3, pp. 336–343, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. B.-N. Pham, J.-F. Mosnier, F. Durand et al., “Immunostaining for membrane attack complex of complement is related to cell necrosis in fulminant and acute hepatitis,” Gastroenterology, vol. 108, no. 2, pp. 495–504, 1995. View at Publisher · View at Google Scholar · View at Scopus
  20. B. Rehermann and M. Nascimbeni, “Immunology of hepatitis B virus and hepatitis C virus infection,” Nature Reviews Immunology, vol. 5, no. 3, pp. 215–229, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. M. M. Markiewski, D. Mastellos, R. Tudoran et al., “C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury,” Journal of Immunology, vol. 173, no. 2, pp. 747–754, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. C. W. Strey, M. Markiewski, D. Mastellos et al., “The proinflammatory mediators C3a and C5a are essential for liver regeneration,” The Journal of Experimental Medicine, vol. 198, no. 6, pp. 913–923, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. D. Mastellos, J. C. Papadimitriou, S. Franchini, P. A. Tsonis, and J. D. Lambris, “A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration,” Journal of Immunology, vol. 166, no. 4, pp. 2479–2486, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. H. E. Kohrt, D. L. Ouyang, and E. B. Keeffe, “Antiviral prophylaxis for chemotherapy-induced reactivation of chronic hepatitis B virus infection,” Clinics in Liver Disease, vol. 11, no. 4, pp. 965–991, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. W.-H. Sheng, J.-H. Kao, P.-J. Chen et al., “Evolution of hepatitis B serological markers in HIV-infected patients receiving highly active antiretroviral therapy,” Clinical Infectious Diseases, vol. 45, no. 9, pp. 1221–1229, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. H. J. Flink, D. Sprengers, B. E. Hansen et al., “Flares in chronic hepatitis B patients induced by the host or the virus? Relation to treatment response during Peg-interferon α-2b therapy,” Gut, vol. 54, no. 11, pp. 1604–1609, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. A. S. F. Lok and C.-L. Lai, “Acute exacerbations in Chinese patients with chronic hepatitis B virus (HBV) infection. Incidence, predisposing factors and etiology,” Journal of Hepatology, vol. 10, no. 1, pp. 29–34, 1990. View at Publisher · View at Google Scholar · View at Scopus
  28. S. K. Sarin, A. Kumar, J. A. Almeida et al., “Acute-on-chronic liver failure; consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL),” Hepatology International, vol. 3, no. 1, pp. 269–282, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. F. Xie, L. Yan, J. Lu et al., “Effects of nucleoside analogue on patients with chronic hepatitis B-associated liver failure: meta-analysis,” PLoS ONE, vol. 8, no. 1, Article ID e54773, 2013. View at Publisher · View at Google Scholar · View at Scopus