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BioMed Research International
Volume 2016 (2016), Article ID 3567275, 13 pages
http://dx.doi.org/10.1155/2016/3567275
Research Article

Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation

1Department of Anaesthetics, Liver Transplant Unit, King’s College Hospital, London, UK
2Neonatology Department, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
3Department of Biopathology, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
4MSc “Cardiopulmonary Resuscitation”, Medical School, National and Kapodistrian University of Athens, Athens, Greece
5ELPEN Research-Experimental Centre, Athens, Greece
62nd Department of Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece
7Division of Pathology, Department of Surgical Sciences, University of Cagliari Medical School, Cagliari, Italy
8School of Medicine, European University Cyprus, Nicosia, Cyprus

Received 19 July 2016; Revised 13 September 2016; Accepted 21 September 2016

Academic Editor: Hideo Inaba

Copyright © 2016 Charalampos Pantazopoulos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To investigate the effect of EPO administration on postresuscitation renal function. Methods. Twenty-four female Landrace/Large-White piglets aged 10–15 weeks with average weight of  kg were randomly assigned to 2 different groups of 12 subjects each. After the end of an 8-minute ventricular fibrillation, the control group (Group C) received saline as placebo, whereas the EPO group (Group E) received EPO 5000 U/kg. The animals were resuscitated according to the 2010 European Resuscitation Council Guidelines for Resuscitation. Results. Five animals (41.67%) from Group C and 11 animals (91.67%) from Group E achieved ROSC (). Eight animals (66.67%, 5 surviving and 3 nonsurviving) from Group C suffered severe kidney damage or AKI compared to animals from Group E, in which none of the swine had evidence of severe kidney damage or AKI (). There was a statistically significant difference in all tested biochemical markers between the two groups, as well as a positive correlation of creatinine with NGAL, L-FABP, and IL-18 (summed mean values’ , 0.01, and 0.004, resp.). Conclusions. Administration of EPO protected swine from postresuscitation acute kidney injury.