Transneuronal Degeneration of Thalamic Nuclei following Middle Cerebral Artery Occlusion in Rats

Figure 7

Expression of myelin basic protein (MBP) on the first day after MCAo. Staining results in (a, b) day 1 and (c, d) day 14 groups. (a, c) Images of the brain regions supplied by the MCA. The red box designates the putamen on the damaged side. The blue box designates the putamen on the control side. (b, d) Images of brain areas not supplied by the MCA. The red box designates the thalamic nuclei on the damaged side. The blue box designates the thalamic nuclei on the control side. No expression of MBP was observed at the damaged site in the 1-day group, and there were no differences in MBP expression between the putamen and thalamus. In the 14-day group, MBP expression was detected both at the damage site and in the thalamus. Again, no differences were observed between the putamen and thalamus with regard to MBP expression. The staining results indicate that levels of MBP expression increased by the 14th day following occlusion and that remyelination may have occurred at the damaged site.

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