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BioMed Research International
Volume 2016, Article ID 3830682, 9 pages
http://dx.doi.org/10.1155/2016/3830682
Research Article

Pacemaker Created in Human Ventricle by Depressing Inward-Rectifier K+ Current: A Simulation Study

1Biocomputing Research Center, School of Computer Science and Technology, Harbin Institute of Technology, Harbin 150001, China
2School of Physics & Astronomy, University of Manchester, Manchester M13 9PL, UK

Received 26 November 2015; Revised 19 January 2016; Accepted 20 January 2016

Academic Editor: Dobromir Dobrev

Copyright © 2016 Yue Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cardiac conduction disorders are common diseases which cause slow heart rate and syncope. The best way to treat these diseases by now is to implant electronic pacemakers, which, yet, have many disadvantages, such as the limited battery life and infection. Biopacemaker has been expected to replace the electronic devices. Automatic ventricular myocytes (VMs) could show pacemaker activity, which was induced by depressing inward-rectifier K+ current (). In this study, a 2D model of human biopacemaker was created from the ventricular endocardial myocytes. We examined the stability of the created biopacemaker and investigated its driving capability by finding the suitable size and spatial distribution of the pacemaker for robust pacing and driving the surrounding quiescent cardiomyocytes. Our results suggest that the rhythm of the pacemaker is similar to that of the single cell at final stable state. The driving force of the biopacemaker is closely related to the pattern of spatial distribution of the pacemaker.