Review Article
Apolipoprotein E Gene Variants and Risk of Coronary Heart Disease: A Meta-Analysis
Table 3
Distribution of Apo E genotypes in case and control groups included in the meta-analysis.
| | First author (year) | Case/control (N/N) | Distribution of apolipoprotein E genotype | | E2/2 | E2/3 | E2/4 | E3/3 | E3/4 | E4/4 | | Case | Control | Case | Control | Case | Control | Case | Control | Case | Control | Case | Control | | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | N (%) |
| | (1) Wang (2004) | 146/340 | 0 (0.0) | 3 (0.9) | 19 (13.0) | 41 (12.1) | 2 (1.3) | 1 (0.3) | 89 (61.0) | 249 (73.2) | 35 (24.0) | 44 (12.9) | 1 (0.7) | 2 (0.6) | | (2) Bai (2001) | 50/47 | 0 (0.0) | 0 (0.0) | 4 (8.0) | 5 (10.6) | 0 (0.0) | 0 (0.0) | 40 (80.0) | 39 (82.99) | 6 (12.0) | 3 (6.4) | 0 (0.0) | 0 (0.0) | | (3) Wang (2004) | 186/350 | 0 (0.0) | 3 (0.9) | 25 (13.4) | 43 (12.3) | 2 (1.1) | 1 (0.3) | 108 (58.1) | 257 (73.4) | 50 (26.9) | 44 (12.6) | 1 (0.5) | 2 (0.6) | | (4) Peng (2001) | 213/180 | 0 (0.0) | 0 (0.0) | 29 (13.6) | 27 (15.0) | 5 (2.3) | 3 (1.7) | 123 (57.7) | 126 (70.0) | 53 (24.9) | 24 (13.3) | 3 (1.4) | 0 (0.0) | | (5) Yang (2001) | 204/136 | 1 (0.5) | 1 (0.7) | 18 (8.8) | 12 (9.0) | 0 (0.0) | 1 (0.7) | 153 (25.0) | 106 (77.9) | 24 (11.8) | 15 (11.0) | 8 (3.9) | 1 (0.7) | | (6) Ouyang (2005) | 200/100 | 1 (0.5) | 0 (0.0) | 28 (14.0) | 17 (17.0) | 1 (1.0) | 1 (0.5) | 98 (49.0) | 66 (66.0) | 67 (33.5) | 14 (14.0) | 5 (2.5) | 2 (2.0) | | (7) Heide (2009) | 121/250 | 0 (0.0) | 0 (0.0) | 7 (5.8) | 31 (12.4) | 4 (3.3) | 5 (2.0) | 88 (72.7) | 163 (65.2) | 19 (15.7) | 49 (19.6) | 3 (2.5) | 2 (0.8) | | (8) Kolovou (2009) | 359/248 | 2 (0.6) | 0 (0.0) | 26 (7.2) | 36 (14.5) | 7 (1.9) | 3 (1.2) | 268 (74.7) | 171 (69.0) | 50 (13.9) | 36 (14.5) | 6 (1.7) | 2 (0.8) | | (9) Bahri (2008) | 80/100 | 0 (0.0) | 0 (0.0) | 6 (7.5) | 8 (8.0) | 0 (0.0) | 1 (1.0) | 61 (76.3) | 78 (78.0) | 13 (16.3) | 13 (13.0) | 0 (0.0) | 0 (0.0) | | (10) Akanji (2007) | 50/65 | 0 (0.0) | 0 (0.0) | 6 (12.0) | 9 (13.8) | 0 (0.0) | 0 (0.0) | 37 (74.0) | 43 (66.2) | 7 (14.0) | 13 (20.0) | 0 (0.0) | 0 (0.0) | | (11) Aydogan (2009) | 41/23 | 0 (0.0) | 0 (0.0) | 4 (9.8) | 3 (13.0) | 0 (0.0) | 1 (4.3) | 28 (68.3) | 15 (65.2) | 9 (22.0) | 4 (17.4) | 0 (0.0) | 0 (0.0) | | (12) Ranjith (2004) | 195/300 | 0 (0.0) | 3 (1.0) | 7 (4.0) | 18 (6.0) | 3 (1.0) | 3 (1.0) | 139 (71.0) | 228 (76.0) | 45 (83.0) | 43 (14.0) | 1 (1.0) | 5 (2.0) | | (13) Peng (2003) | 150/157 | 1 (0.7) | 1 (0.6) | 21 (14.0) | 13 (8.3) | 1 (0.7) | 1 (0.6) | 93 (62.0) | 122 (77.7) | 30 (20.0) | 18 (11.5) | 4 (2.7) | 2 (1.7) | | (14) Singh (2008) | 193/150 | 1 (0.5) | 1 (0.7) | 15 (7.8) | 19 (12.7) | 4 (2.1) | 2 (1.3) | 123 (63.7) | 112 (74.7) | 46 (23.8) | 14 (9.7) | 4 (2.1) | 2 (1.3) | | (15) Keavney (2003) | 4484/5757 | 34 (0.8) | 44 (0.8) | 440 (9.8) | 686 (11.9) | 101 (2.3) | 137 (2.4) | 2566 (57.2) | 3384 (58.8) | 1206 (26.9) | 1376 (23.9) | 137 (13.0) | 130 (2.2) | | (16) Freitas (2002) | 640/624 | 5 (0.8) | 4 (0.6) | 37 (5.8) | 67 (10.7) | 14 (2.2) | 15 (2.4) | 396 (62.0) | 372 (60.0) | 173 (27.0) | 147 (24.0) | 15 (2.3) | 19 (3.0) | | (17) Kawakami (2001) | 225/213 | 3 (1.2) | 0 (0.0) | 6 (2.7) | 13 (6.1) | 1 (0.4) | 2 (0.9) | 177 (78.7) | 140 (65.7) | 30 (1.3) | 56 (26.3) | 8 (3.6) | 2 (0.9) | | (18) Attila (2001) | 107/92 | 9 (8.4) | 4 (4.3) | 7 (6.5) | 7 (7.6) | 0 (0.0) | 0 (0.0) | 71 (66.4) | 75 (81.6) | 18 (16.8) | 5 (5.4) | 2 (1.9) | 1 (1.1) | | (19) Kharrazi (2006) | 115/135 | 0 (0.0) | 0 (0.0) | 18 (15.7) | 11 (8.1) | 0 (0.0) | 0 (0.0) | 54 (47.0) | 115 (85.2) | 43 (37.4) | 9 (6.7) | 0 (0.0) | 0 (0.0) | | (20) Gamboa (2008) | 156/200 | 0 (0.0) | 4 (2.0) | 5 (3.2) | 1 (0.5) | 0 (0.0) | 0 (0.0) | 127 (81.4) | 168 (84.0) | 24 (15.4) | 27 (13.5) | 0 (0.0) | 0 (0.0) | | (21) Al-Yahyaee (2007) | 67/177 | 0 (0.0) | 0 (0.0) | 1 (1.5) | 6 (3.4) | 0 (0.0) | 0 (0.0) | 60 (89.6) | 158 (89.3) | 6 (9.0) | 13 (7.3) | 0 (0.0) | 0 (0.0) | | (22) Al-Bustan (2009) | 143/122 | 8 (5.6) | 9 (7.3) | 3 (2.1) | 2 (1.6) | 2 (1.4) | 3 (2.5) | 114 (79.7) | 98 (80.3) | 15 (10.5) | 9 (7.4) | 1 (0.7) | 1 (0.8) | | (23) Vaisi-Raygani (2010) | 162/179 | 0 (0) | 6 (3.4) | 31 (19.1) | 26 (14.5) | 0 (0) | 2 (1.1) | 99 (61.1) | 119 (66.5) | 28 (17.3) | 24 (13.4) | 4 (2.5) | 2 (1.1) | | (24) Corella (2011) | 534/1123 | 1 (0.1) | 1 (0) | 33 (6.2) | 105 (9.3) | 7 (1.3) | 16 (1.4) | 400 (74.9) | 828 (73.7) | 91 (17.0) | 167 (14.8) | 2 (0.4) | 6 (0.5) | | (25) Fallah (2011) | 190/200 | 13 (6.8) | 7 (3.5) | 10 (5.3) | 22 (11.0) | 37 (19.5) | 19 (9.5) | 35 (18.4) | 59 (29.5) | 61 (32.1) | 78 (39.0) | 34 (17.9) | 15 (7.5) | | (26) Gustavsson (2012) | 1735/4654 | 11 (0.6) | 32 (0.7) | 133 (7.8) | 547 (11.8) | 44 (2.5) | 127 (2.7) | 1044 (60.2) | 2689 (57.8) | 451 (26.0) | 1140 (24.5) | 52 (3.0) | 119 (2.6) | | (27) Heidari (2013) | 66/61 | 8 (12.1) | 7 (11.5) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 52 (78.8) | 54 (88.5) | 6 (9.1) | 0 (0) | 0 (0) | 0 (0) | | (28) Marrzoq (2011) | 69/68 | 0 (0) | 0 (0) | 5 (7.2) | 7 (10.3) | 0 (0) | 0 (0) | 45 (65.2) | 51 (75.0) | 19 (27.5) | 10 (14.7) | 0 (0) | 0 (0) | | (29) Afroze (2015) | 200/450 | 2 (1) | 9 (2) | 18 (9) | 36 | 4 (2) | 12 (2.7) | 110 (55) | 315 (7) | 53 (26.5) | 66 (14.7) | 13 (6.5) | 12 (2.7) | | (30) Sapkota (2015) | 723/1212 | 1 (0.1) | 1 (0) | 46 (6.4) | 83 (6.8) | 4 (0.5) | 10 (0.8) | 572 (79.1) | 977 (80.6) | 95 (13.1) | 137 (11.3) | 5 (0.7) | 4 (0.3) |
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