Hepatoepigenetic Alterations in Viral and Nonviral-Induced Hepatocellular Carcinoma

Table 1

Strategies of HCC treatment by combining epigenetic drugs and immunotherapy.

Combination	Outcome	References
Guadecitabine plus oxaliplatin	Inhibition in cell growth and proliferation	[159]
Azacytidine plus alendronate	Increased cell cytotoxicity and suppression of tumour growth	[160]
Azacytidine plus vitamin C	Suppression of cell proliferation and induction of cell cycle arrest	[57]
Decitabine plus SAHA	Reduces cell growth and proliferation	[157]
Azacytidine plus TRAIL	Prevents protein biosynthesis and induces apoptosis	[158]
Vorinostat plus sorafenib	Inhibition of tumour growth	[165]
Belinostat plus bortezomib	Suppression of cell proliferation and induction of cell cycle arrest	[170]