Anticonvulsant and Toxicological Evaluation of Parafluorinated/Chlorinated Derivatives of 3-Hydroxy-3-ethyl-3-phenylpropionamide

Figure 1

The effect of the tested compounds on two seizure models. (a) The effect of administering the ED₅₀ against maximal electroshock seizures: HEPP = 129.6 mg/kg, F-HEPP = 87.1 mg/kg, Cl-HEPP = 62.0 mg/kg, sodium valproate = 261.2 mg/kg, and phenobarbital = 16.9 mg/kg; (b) the effect of administering the ED₅₀ against pentylenetetrazole seizures: HEPP = 66.4 mg/kg, F-HEPP = 43.5 mg/kg, Cl-HEPP = 43.5 mg/kg, sodium valproate = 159.7 mg/kg, and phenobarbital = 12.9 mg/kg. . Black bar, mice with seizures; grey bar, mice without seizures; ISS, isotonic saline solution (NaCl 0.09%); PEG-400 (30%), polyethyilenglicol-400 at 30% with ISS. For the hypothesis test, the percentage of protection was 50% in order to determine the proportion response of the antiepileptic drugs. According to the -test, there was no statistically significant difference between mice protected against seizures with antiepileptic drugs and unprotected mice.

(a)

(b)