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BioMed Research International
Volume 2016, Article ID 3978010, 10 pages
http://dx.doi.org/10.1155/2016/3978010
Research Article

Anticonvulsant and Toxicological Evaluation of Parafluorinated/Chlorinated Derivatives of 3-Hydroxy-3-ethyl-3-phenylpropionamide

1Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, 15500 México City, DF, Mexico
2Laboratorio de Quimioterapia Experimental, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, 11350 México City, DF, Mexico
3Laboratorio de Farmacología Molecular, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, 11340 México City, DF, Mexico
4Departamento de Fisiología, Escuela Superior de Medicina, Instituto Politécnico Nacional, 11340 México City, DF, Mexico
5Laboratorio de Modelado Molecular y Diseño de Fármacos, Escuela Superior de Medicina, Instituto Politécnico Nacional, 11340 México City, DF, Mexico
6Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran 19419, Iran
7Laboratorio de Toxicología Preclínica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, 11350 México City, DF, Mexico

Received 19 September 2015; Revised 21 January 2016; Accepted 26 January 2016

Academic Editor: Rituraj Purohit

Copyright © 2016 Osvaldo Garrido-Acosta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Material includes the docking results for (S)-configuration of tested ligands on GABAA receptor or the sodium channel Nav1.2, as well as the energy values and residues involved in the recognition for all tested ligands.

  1. Supplementary Material