Anticonvulsant and Toxicological Evaluation of Parafluorinated/Chlorinated Derivatives of 3-Hydroxy-3-ethyl-3-phenylpropionamide

Table 1

ED₅₀ and confidence limits of HEPP and its fluorinated and chlorinated derivatives against MES and PTZ.

Treatments	MES; mg/kg	C.L.; 95%	PTZ; mg/kg	C.L.; 95%
HEPP	129.6	14% to 70%	66.4	14% to 70%
F-HEPP	87.1	14% to 70%	43.5	14% to 70%
Cl-HEPP	62.0	14% to 70%	43.5	22% to 78%
Sodium valproate	261.2	14% to 70%	159.7	22% to 78%
Phenobarbital	16.3	30% to 86%	12.7	14% to 70%

MES: maximal electroshock; PTZ: pentylenetetrazole; HEPP: 3-hydroxy-3-ethyl-3-phenylpropionamide; F-HEPP: 3-hydroxy, 3-ethyl, 3-(4′-fluorophenyl)propioanamide; Cl-HEPP: 3-hydroxy, 3-ethyl, 3-(4′-chlorophenyl)propionamide; C.L.: confidence limits of the expected fraction.