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Abbreviation | Description |
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Clumping factor A (clfA) | Cell surface-associated protein implicated in virulence, promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen, induces formation of bacterial clumps (933 aa) |
Clumping factor B (clfB) | Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps (913 aa) |
Cold shock protein (cspA) | Involved in cold stress response and in the susceptibility to an antimicrobial peptide of human cathepsin G (CG117-136). Regulates yellowish-orange pigment production through a still unclear SigB-dependent mechanism (66 aa) |
Elastin-binding protein (ebpS) | Promotes binding of soluble elastin peptides and tropoelastin to S. aureus cells although it is not able to promote bacterial adherence to immobilized elastin and, therefore, is not a Microbial Surface Component Recognizing Adhesive Matrix Molecule (MSCRAMM) (486 aa) |
Enolase (eno) | Phosphopyruvate hydratase; catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate; it is essential for the degradation of carbohydrates via glycolysis; binds laminin when expressed on the bacterial cell surface; this probably induces destruction of the extracellular matrix, favoring invasion and dissemination (434 aa) |
Extracellular adherence protein (eap) | Adherence and invading of eukaryotic cells (985 aa) |
Fibrinogen-binding protein (fib) | Binds to host fibrinogen (165 aa) |
Fibronectin-binding protein A (fnb) | Promotes bacterial attachment to multiple substrates, such as fibronectin (Fn), fibrinogen (Fg), elastin peptides, and tropoelastin; this confers to S. aureus the ability to invade endothelial cells; promotes adherence to and aggregation of activated platelets (1018 aa) |
Foldase protein (prsA) | Export protein; plays a major role in protein secretion by helping the posttranslocational extracellular folding of several secreted proteins (320 aa) |
IgG-binding protein SBI (sbi) | Interacts with components of both the adaptive and innate host immune system, thereby protecting the cell against the host immune response (436 aa) |
Immunoglobulin G-binding protein A (spA) | Function in pathogenesis (508 aa) |
Immunoglobulin G-binding protein Sbi | Interacts with components of both the adaptive and innate host immune system, thereby protecting the cell against the host immune response (436 aa) |
Immunoglobulin-binding protein (sbi) | Interacts with components of both the adaptive and innate host immune system, thereby protecting the cell against the host immune response (436 aa) |
Iron-regulated surface determinant protein A (isdA) | LPXTG cell-wall surface anchor protein; transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor; the reaction is reversible; binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin, protein A; also binds fibronectin and chains B, beta and gamma of fibrinogen, promoting clumping of S. aureus with fibrinogen; was also shown to adhere to plastic (350 aa) |
Large-conductance mechanosensitive channel (mscL) | Channel that opens in response to stretch forces in the membrane lipid bilayer; may participate in the regulation of osmotic pressure changes within the cell (120 aa) |
Lipoteichoic acid synthase (ltaS) | Sulfatase; catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate, a reaction that presumably uses phosphatidylglycerol (PG) as substrate is required for staphylococcal growth and cell division process (646 aa) |
N-acetylmuramoyl-L-alanine amidase (sle1) | Peptidoglycan hydrolase involved in the splitting of the septum during cell division; binds to both alpha- and beta-chains of human fibrinogen as well as fibronectin, which suggests a role in the colonization of host factor-coated material or host tissue; also exhibits lytic activity against S. carnosus and S. aureus cells but not against M. luteus cells (334 aa) |
Penicillin-binding protein 1 (pbp1) | Penicillin-binding protein 1 (744 aa) |
Phospholipase C (hlb) | Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture; beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins; has a high specificity for sphingomyelin and hydrolyzes lysophosphatidylcholine at a much lower rate but has no activity toward phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (330 aa) |
Probable transglycosylase (sceD) | Cleaves peptidoglycan and affects clumping and separation of bacterial cells (231 aa) |
Secretory antigen SsA-like protein | Immunogenic protein (267 aa) |
Serine-aspartate repeat-containing protein C (sdrC) | sdrC protein; cell surface-associated protein which possibly mediates interactions of S. aureus with components of the extracellular matrix of higher eukaryotes; may bind calcium (947 aa) |
Staphylococcal secretory antigen Ss aa2 (scaD) | Immunogenic protein (265 aa) |
Virulence factor (esxA) | Hypothetical protein; virulence factor that is important for the establishment of infection in the host (97 aa) |
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