Table 3: Description of proteins listed in Table 2.


Clumping factor A (clfA)Cell surface-associated protein implicated in virulence, promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen, induces formation of bacterial clumps (933 aa)
Clumping factor B (clfB)Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps (913 aa)
Cold shock protein (cspA)Involved in cold stress response and in the susceptibility to an antimicrobial peptide of human cathepsin G (CG117-136). Regulates yellowish-orange pigment production through a still unclear SigB-dependent mechanism (66 aa)
Elastin-binding protein (ebpS)Promotes binding of soluble elastin peptides and tropoelastin to S. aureus cells although it is not able to promote bacterial adherence to immobilized elastin and, therefore, is not a Microbial Surface Component Recognizing Adhesive Matrix Molecule (MSCRAMM) (486 aa)
Enolase (eno)Phosphopyruvate hydratase; catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate; it is essential for the degradation of carbohydrates via glycolysis; binds laminin when expressed on the bacterial cell surface; this probably induces destruction of the extracellular matrix, favoring invasion and dissemination (434 aa)
Extracellular adherence protein (eap)Adherence and invading of eukaryotic cells (985 aa)
Fibrinogen-binding protein (fib)Binds to host fibrinogen (165 aa)
Fibronectin-binding protein A (fnb)Promotes bacterial attachment to multiple substrates, such as fibronectin (Fn), fibrinogen (Fg), elastin peptides, and tropoelastin; this confers to S. aureus the ability to invade endothelial cells; promotes adherence to and aggregation of activated platelets (1018 aa)
Foldase protein (prsA)Export protein; plays a major role in protein secretion by helping the posttranslocational extracellular folding of several secreted proteins (320 aa)
IgG-binding protein SBI (sbi)Interacts with components of both the adaptive and innate host immune system, thereby protecting the cell against the host immune response (436 aa)
Immunoglobulin G-binding protein A (spA)Function in pathogenesis (508 aa)
Immunoglobulin G-binding protein SbiInteracts with components of both the adaptive and innate host immune system, thereby protecting the cell against the host immune response (436 aa)
Immunoglobulin-binding protein (sbi)Interacts with components of both the adaptive and innate host immune system, thereby protecting the cell against the host immune response (436 aa)
Iron-regulated surface determinant protein A (isdA)LPXTG cell-wall surface anchor protein; transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor; the reaction is reversible; binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin, protein A; also binds fibronectin and chains B, beta and gamma of fibrinogen, promoting clumping of S. aureus with fibrinogen; was also shown to adhere to plastic (350 aa)
Large-conductance mechanosensitive channel (mscL)Channel that opens in response to stretch forces in the membrane lipid bilayer; may participate in the regulation of osmotic pressure changes within the cell (120 aa)
Lipoteichoic acid synthase (ltaS)Sulfatase; catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate, a reaction that presumably uses phosphatidylglycerol (PG) as substrate is required for staphylococcal growth and cell division process (646 aa)
N-acetylmuramoyl-L-alanine amidase (sle1)Peptidoglycan hydrolase involved in the splitting of the septum during cell division; binds to both alpha- and beta-chains of human fibrinogen as well as fibronectin, which suggests a role in the colonization of host factor-coated material or host tissue; also exhibits lytic activity against S. carnosus and S. aureus cells but not against M. luteus cells (334 aa)
Penicillin-binding protein 1 (pbp1)Penicillin-binding protein 1 (744 aa)
Phospholipase C (hlb)Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture; beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins; has a high specificity for sphingomyelin and hydrolyzes lysophosphatidylcholine at a much lower rate but has no activity toward phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (330 aa)
Probable transglycosylase (sceD)Cleaves peptidoglycan and affects clumping and separation of bacterial cells (231 aa)
Secretory antigen SsA-like proteinImmunogenic protein (267 aa)
Serine-aspartate repeat-containing protein C (sdrC)sdrC protein; cell surface-associated protein which possibly mediates interactions of S. aureus with components of the extracellular matrix of higher eukaryotes; may bind calcium (947 aa)
Staphylococcal secretory antigen Ss aa2 (scaD)Immunogenic protein (265 aa)
Virulence factor (esxA)Hypothetical protein; virulence factor that is important for the establishment of infection in the host (97 aa)