New Therapeutic Concept of NAD Redox Balance for Cisplatin Nephrotoxicity

Figure 2

Substrates for NQO1. (a) Naturally occurring quinones as antioxidants. (b) Substrates for reduction by NQO1 and reactive quinone metabolites (benzoquinone, naphthoquinone, and quinoneimine). (c) Naturally occurring quinones with anticancer properties. QS-10: 6-(9-carboxynonyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone, AZQ: Diaziquine, MeDZQ: 2,5-diaziridinyl-3,6-dimethyl-1,4-benzoquinone, and RH1: 2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone.

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(b)

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