Docosahexaenoic Acid Rescues Synaptogenesis Impairment and Long-Term Memory Deficits Caused by Postnatal Multiple Sevoflurane Exposures
DHA attenuated sevoflurane-induced decreases in the PSD95 and synaptophysin expressions. (a) DHA (15 μg/g) was administered intraperitoneally 30 mins before each treatment with 3% sevoflurane for 2 h in three consecutive days. Immediately after the last exposure, the expression levels of PSD95, synaptophysin, and β-actin in the hippocampus tissues of mice were determined by Western blot analysis. (b) The histogram shows the levels of synaptophysin/β-actin ratio in (a). (c) The histogram shows the levels of PSD95/β-actin ratio in (a). All data are presented as mean ± SEM; comparing with control group, for each group. Sevo = sevoflurane.
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