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BioMed Research International
Volume 2016 (2016), Article ID 4130834, 7 pages
http://dx.doi.org/10.1155/2016/4130834
Research Article

High Mobility Group Box1 Protein Is Involved in Endoplasmic Reticulum Stress Induced by Clostridium difficile Toxin A

1School of Bioscience & Bioengineering, South China University of Technology, Guangzhou 510006, China
2Guangdong Province Key Laboratory of Fermentation and Enzyme Engineering, South China University of Technology, Guangzhou 510006, China

Received 26 April 2016; Accepted 5 July 2016

Academic Editor: Jiazhang Lian

Copyright © 2016 Ji Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Kyne, “Clostridium difficile—beyond antibiotics,” The New England Journal of Medicine, vol. 362, no. 3, pp. 264–265, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. B. Elliott, B. J. Chang, C. L. Golledge, and T. V. Riley, “Clostridium difficile-associated diarrhoea,” Journal of International Medicine, vol. 37, no. 8, pp. 561–568, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. C. P. Kelly, C. Pothoulakis, and J. T. Lamont, “Clostridium difficile colitis,” The New England Journal of Medicine, vol. 330, no. 4, pp. 257–262, 1994. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Yang, B. Zhou, J. Wang et al., “Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium,” BMC Microbiology, vol. 8, article 192, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Matarrese, L. Falzano, A. Fabbri et al., “Clostridium difficile toxin B causes apoptosis in epithelial cells by thrilling mitochondria: involvement of ATP-sensitive mitochondrial potassium channels,” The Journal of Biological Chemistry, vol. 282, no. 12, pp. 9029–9041, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Fiorentini, A. Fabbri, L. Falzano et al., “Clostridium difficile toxin B induces apoptosis in intestinal cultured cells,” Infection and Immunity, vol. 66, pp. 2660–2665, 1998. View at Google Scholar
  7. M. Warny, A. C. Keates, S. Keates et al., “p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis,” The Journal of Clinical Investigation, vol. 105, no. 8, pp. 1147–1156, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. U. Andersson and K. J. Tracey, “HMGB1 is a therapeutic target for sterile inflammation and infection,” Annual Review of Immunology, vol. 29, pp. 139–162, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Yanai, T. Ban, and T. Taniguchi, “Essential role of high-mobility group box proteins in nucleic acid-mediated innate immune responses,” Journal of Internal Medicine, vol. 270, no. 4, pp. 301–308, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Štros, “HMGB proteins: interactions with DNA and chromatin,” Biochimica et Biophysica Acta—Gene Regulatory Mechanisms, vol. 1799, no. 1-2, pp. 101–113, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Wang, O. Bloom, M. Zhang et al., “HMG-1 as a late mediator of endotoxin lethality in mice,” Science, vol. 285, no. 5425, pp. 248–251, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. S. P. Caffidi, T. Misteli, and M. E. Bianchi, “Release ofvchromatin protein HMGB1 by necrotic cells triggers inflammation,” Nature, vol. 418, pp. 191–195, 2002. View at Publisher · View at Google Scholar
  13. S. S. Lange, D. L. Mitchell, and K. M. Vasquez, “High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damage,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 30, pp. 10320–10325, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. M. T. Lotze and K. J. Tracey, “High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal,” Nature Reviews Immunology, vol. 5, no. 4, pp. 331–342, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Liu, B. L. Zhang, C. L. Sun, S. Li, and J. F. Wang, “High mobility group box1 protein is involved in acute inflammation induced by Clostridium difficile toxin A,” Acta Biochimica et Biophysica Sinica, vol. 48, no. 6, pp. 554–562, 2016. View at Publisher · View at Google Scholar
  16. B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts, and P. Walter, Molecular Biology of the Cell, Garland Science, New York, NY, USA, 2002.
  17. R. J. Kaufman, “Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls,” Genes and Development, vol. 13, no. 10, pp. 1211–1233, 1999. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Schröder and R. J. Kaufman, “ER stress and the unfolded protein response,” Mutation Research, vol. 569, no. 1-2, pp. 29–63, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. X. Chen, E. G. Kokkotou, N. Mustafa et al., “Saccharomyces boulardii inhibits ERK1/2 mitogen-activated protein kinase activation both in vitro and in vivo and protects against Clostridium difficile toxin A-induced enteritis,” The Journal of Biological Chemistry, vol. 281, no. 34, pp. 24449–24454, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. B. Qiu, C. Pothoulakis, I. Castagliuolo, S. Nikulasson, and J. T. LaMont, “Participation of reactive oxygen metabolites in Clostridium difficile toxin A-induced enteritis in rats,” American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 276, no. 2, pp. G485–G490, 1999. View at Google Scholar · View at Scopus
  21. N. M. Sullivan, S. Pellett, and T. D. Wilkins, “Purification and characterization of toxins A and B of Clostridium difficile,” Infection and Immunity, vol. 35, no. 3, pp. 1032–1040, 1982. View at Google Scholar · View at Scopus
  22. C. R. Bromati, C. Lellis-Santos, T. S. Yamanaka et al., “UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression,” American Journal of Physiology—Regulatory Integrative and Comparative Physiology, vol. 300, no. 1, pp. R92–R100, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Mollica, F. De Marchis, A. Spitaleri et al., “Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities,” Chemistry & Biology, vol. 14, no. 4, pp. 431–441, 2007. View at Publisher · View at Google Scholar
  24. L. Zhao and S. L. Ackerman, “Endoplasmic reticulum stress in health and disease,” Current Opinion in Cell Biology, vol. 18, no. 4, pp. 444–452, 2006. View at Publisher · View at Google Scholar · View at Scopus