Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2016, Article ID 4302754, 9 pages
http://dx.doi.org/10.1155/2016/4302754
Research Article

Seminal miRNA Relationship with Apoptotic Markers and Oxidative Stress in Infertile Men with Varicocele

1Department of Andrology & Sexology, Faculty of Medicine, Cairo University, Cairo, Egypt
2Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt
3Department of Andrology and Sexology, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt
4Department of Andrology and Sexology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Received 9 August 2016; Accepted 16 November 2016

Academic Editor: Robert Stoehr

Copyright © 2016 Taymour Mostafa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Abhari, N. Zarghami, V. Shahnazi et al., “Significance of microRNA targeted estrogen receptor in male fertility,” Iranian Journal of Basic Medical Sciences, vol. 17, no. 2, pp. 81–86, 2014. View at Google Scholar · View at Scopus
  2. W.-L. Jiang, Y.-F. Zhang, Q.-Q. Xia et al., “MicroRNA-19a regulates lipopolysaccharide-induced endothelial cell apoptosis through modulation of apoptosis signal-regulating kinase 1 expression,” BMC Molecular Biology, vol. 16, article no. 11, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. G. C. Ostermeier, D. J. Dix, D. Miller, P. Khatri, and S. A. Krawetz, “Spermatozoal RNA profiles of normal fertile men,” Lancet, vol. 360, no. 9335, pp. 772–777, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Wang, C. Yang, X. Chen et al., “Altered profile of seminal plasma microRNAs in the molecular diagnosis of male infertility,” Clinical Chemistry, vol. 57, no. 12, pp. 1722–1731, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. J.-L. Park, S.-M. Park, O.-H. Kwon et al., “Microarray screening and qRT-PCR evaluation of microRNA markers for forensic body fluid identification,” Electrophoresis, vol. 35, no. 21-22, pp. 3062–3068, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Sadek, A. S. A. Almohamdy, A. Zaki, M. Aref, S. M. Ibrahim, and T. Mostafa, “Sperm chromatin condensation in infertile men with varicocele before and after surgical repair,” Fertility and Sterility, vol. 95, no. 5, pp. 1705–1708, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Zalata, M. El-Mogy, A. Abdel-Khabir, Y. El-Bayoumy, M. El-Baz, and T. Mostafa, “Sperm caspase-9 in oligoasthenoteratozoospermic men with and without varicocele,” Fertility and Sterility, vol. 96, no. 5, pp. 1097–1099, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Hassan, E. M. El-Nashar, and T. Mostafa, “Programmed cell death in varicocele-bearing testes,” Andrologia, vol. 41, no. 1, pp. 39–45, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Zedan, A. W. M. M. El-Mekhlafi, A. M. El-Noweihi, N. E. Abd El-Azim, and T. Mostafa, “Soluble Fas and gonadal hormones in infertile men with varicocele,” Fertility and Sterility, vol. 91, no. 2, pp. 420–424, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. G. A. Tawadrous, A. A. Aziz, and T. Mostafa, “Seminal soluble fas relationship with oxidative stress in infertile men with varicocele,” Urology, vol. 82, no. 4, pp. 820–823, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. World Health Organization, WHO Laboratory Manual for the Examination and Processing of Human Semen, WHO Press, Geneva, Switzerland, 5th edition, 2010.
  12. T. M. Motawi, S. M. Rizk, O. G. Shaker, O. Z. Mokhtar, and D. R. Booth, “MicroRNAs as predictor markers for response to interferon treatment of chronic hepatitis C genotype-4 in Egyptian patients,” PLoS One, vol. 10, no. 3, Article ID e0121524, 2015. View at Publisher · View at Google Scholar
  13. Z. A. Placer, L. L. Cushman, and B. C. Johnson, “Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems,” Analytical Biochemistry, vol. 16, no. 2, pp. 359–364, 1966. View at Publisher · View at Google Scholar · View at Scopus
  14. H. H. Draper, E. J. Squires, H. Mahmoodi, J. Wu, S. Agarwal, and M. Hadley, “A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials,” Free Radical Biology and Medicine, vol. 15, no. 4, pp. 353–363, 1993. View at Publisher · View at Google Scholar · View at Scopus
  15. S. El-Haggar, L. Rashed, N. Y. Saleh, M. Taymour, and T. Mostafa, “Seminal osteopontin relationship with semen variables in infertile men with varicocele,” Human Andrology, vol. 3, no. 4, pp. 90–93, 2013. View at Publisher · View at Google Scholar
  16. D. E. Paglia and W. N. Valentine, “Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase,” The Journal of Laboratory and Clinical Medicine, vol. 70, no. 1, pp. 158–169, 1967. View at Google Scholar · View at Scopus
  17. T. Mostafa, L. Rashed, N. Nabil, and R. Amin, “Seminal BAX and BCL2 gene and protein expressions in infertile men with varicocele,” Urology, vol. 84, no. 3, pp. 590–595, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Mostafa, T. Anis, H. Imam, A. R. El-Nashar, and I. A. Osman, “Seminal reactive oxygen species-antioxidant relationship in fertile males with and without varicocele,” Andrologia, vol. 41, no. 2, pp. 125–129, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Garolla, M. Torino, P. Miola et al., “Twenty-four-hour monitoring of scrotal temperature in obese men and men with a varicocele as a mirror of spermatogenic function,” Human Reproduction, vol. 30, no. 5, pp. 1006–1013, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. B. McCallie, W. B. Schoolcraft, and M. G. Katz-Jaffe, “Aberration of blastocyst microRNA expression is associated with human infertility,” Fertility and Sterility, vol. 93, no. 7, pp. 2374–2382, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. W.-M. Liu, R. T. K. Pang, P. C. N. Chiu et al., “Sperm-borne microRNA-34c is required for the first cleavage division in mouse,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 2, pp. 490–494, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. Z. Ji, R. Lu, L. Mou et al., “Expressions of miR-15a and its target gene HSPA1B in the spermatozoa of patients with varicocele,” Reproduction, vol. 147, no. 5, pp. 693–701, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Wenhao, L. De-Feng, H. Kai et al., “miRNA-mediated regulation of heat shock proteins in human ejaculated spermatozoa,” Turkish Journal of Medical Sciences, vol. 45, no. 6, pp. 1285–1291, 2015. View at Publisher · View at Google Scholar · View at Scopus
  24. G. Vivas-Acevedo, J. R. Lozano, and M. I. Camejo, “Effect of varicocele grade and age on seminal parameters,” Urologia Internationalis, vol. 85, no. 2, pp. 194–199, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. T. Mostafa, T. Anis, A. El Nashar, H. Imam, and I. Osman, “Seminal plasma reactive oxygen species-antioxidants relationship with varicocele grade,” Andrologia, vol. 44, no. 1, pp. 66–69, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Cocuzza, K. S. Athayde, C. Alvarenga, M. Srougi, and J. Hallak, “Grade 3 varicocele in fertile men: a different entity,” Journal of Urology, vol. 187, no. 4, pp. 1363–1368, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Mostafa, L. Rashed, and M. Taymour, “Seminal cyclooxygenase relationship with oxidative stress in infertile oligoasthenoteratozoospermic men with varicocele,” Andrologia, vol. 48, no. 2, pp. 137–142, 2016. View at Publisher · View at Google Scholar · View at Scopus