Research Article

Estrogen Modulates Expression of Tight Junction Proteins in Rat Vagina

Figure 1

(a) Immunohistochemistry of zonula occludens- (ZO-) 1 in vaginal tissue from animals of the control (Con), ovariectomy (Ovx), and ovariectomy plus 17β-estradiol treatment (Ovx + Est) groups. ZO-1 was mainly expressed in the superficial epithelium. (b) Immunoblotting of ZO-1 in the rat vagina. The lower panels denote the means ± standard error of 6 experiments for each condition determined by densitometry relative to beta-actin. versus control. versus Ovx.
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