Molecular Role of EGFR-MAPK Pathway in Patchouli Alcohol-Induced Apoptosis and Cell Cycle Arrest on A549 Cells In Vitro and In Vivo
Growth inhibition and apoptosis effect of PA. (a) The chemical structure of PA. (b) Inhibition effect of PA on A549 cells using MTT assay. (c) Effect of PA on HEK293, L02, and HFL-1 cells for 48 h using MTT assay. (d) The increasing tendency of apoptotic ratio induced by increasing PA concentrations of 0, 50, 75, and 100 μg/mL and 75 μg/mL combined with EGF. (e) Mechanism of PA induced apoptosis on A549 cells. A549 cells were exposed for 48 h with increasing PA. Proteins levels were probed by western blotting assay. Statistical differences were compared between PA treatment group and control group and considered significant at the levels of or .
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.