Inhibitor of DNA Binding 1 Is Induced during Kidney Ischemia-Reperfusion and Is Critical for the Induction of Hypoxia-Inducible Factor-1α

Figure 1

ID1 and HIF-1α protein induction in the rat I/R injury model. (a, b) Western blot analysis of ID1 and HIF-1α expression in the kidney cortex after I/R. The expression of β-actin was examined as the loading control. A representative blot from 3 independent experiments is shown. (c, d) The histogram shows the average volume densities corrected for β-actin (). compared with the preischemia controls. ID1, inhibitor of DNA binding 1; HIF-1α, hypoxia-inducible factor-1 alpha; I/R, ischemia-reperfusion.

(a)

(b)

(c)

(d)