Inhibitor of DNA Binding 1 Is Induced during Kidney Ischemia-Reperfusion and Is Critical for the Induction of Hypoxia-Inducible Factor-1α

Figure 2

Location of ID1 and HIF-1α expression in I/R-injured rat kidney tissue. Immunohistochemical staining for ID1 and HIF-1α in the kidney tissue of I/R and sham-operated rats. (a) Increased staining for ID1 in renal TECs after 2, 6, 12, and 24 hours of reperfusion. (b) Increased staining for HIF-1α in renal TECs after 2 hours of reperfusion. Original magnification, ×200. ID1, inhibitor of DNA binding 1; HIF-1α, hypoxia-inducible factor-1 alpha; I/R, ischemia-reperfusion; TECs, tubular epithelial cells.

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