BioMed Research International / 2016 / Article / Tab 1

Clinical Study

Combination of Intra-Articular and Intraosseous Injections of Platelet Rich Plasma for Severe Knee Osteoarthritis: A Pilot Study

Table 1

Demographic data and biological and clinical outcomes.

Demographic data
PatientsTotal: Men: (%)Women: (%)Age: mean ± SD (range)OA III: (%)OA IV: (%)

139 (69.23)4 (30.77)62.23 ± 9.6 (47–75)9 (69.23)4 (30.77)

Biological outcomes
Baseline: mean ± SDOne week after infiltration: mean ± SD

MSC/μL7.98 ± 8.214.04 ± 5.360.019
CFU-F/mL601.75 ± 312.30139.19 ± 123.610.012

Clinical outcomes
Baseline: mean ± SDEndpoint: mean ± SDδ: mean ± SD (% change)Improved patients: (%)Patients with MCII [22]: (%)

KOOS pain61.55 ± 14.1174.60 ± 19.190.00813.10 ± 14.89 (24.19 ± 40.07)11 (84.62)8 (61.53)
KOOS symptoms60.56 ± 17.3571.70 ± 18.820.00411.14 ± 11.34 (19.73 ± 25.42)11 (84.62)8 (61.53)
KOOS ADL68.44 ± 14.0880.86 ± 15.580.02212.45 ± 17.31 (23.25 ± 38.82)11 (84.62)8 (61.53)
KOOS sport/rec.29.23 ± 20.2945.38 ± 22.400.01711.78 ± 11.54 (76.94 ± 115.23)10 (76.92)7 (53.84)
KOOS QOL28.10 ± 19.7539.28 ± 16.520.01214.90 ± 22.03 (66.66 ± 72.64)11 (84.62)8 (61.53)
VAS6.77 ± 1.752.88 ± 2.48<0.001−3.88 ± 2.82 (−55.04 ± 38.21)11 (84.62)10 (76.92)
Lequesne Index8.69 ± 2.655.77 ± 3.490.008−2.92 ± 3.35 (−31.18 ± 46.61)10 (76.92)

OA: osteoarthritis; MSC: mesenchymal stem cells; CFU-F: cultures of colony-forming cells; VAS: visual analogue scale; KOOS: knee injury and osteoarthritis outcome score; ADL: function in daily living; sport/rec.: function in sport and recreation; QOL: quality of life; δ: difference from baseline. MCII: minimal clinically important improvement; with respect to basal level.

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