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BioMed Research International
Volume 2016, Article ID 5040814, 10 pages
Review Article

Near-Infrared Fluorescence-Enhanced Optical Tomography

1Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA
2Optical Imaging Laboratory, Department of Biomedical Engineering, Florida International University, Miami, FL 33174, USA

Received 1 July 2016; Accepted 25 August 2016

Academic Editor: Shouping Zhu

Copyright © 2016 Banghe Zhu and Anuradha Godavarty. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Fluorescence-enhanced optical imaging using near-infrared (NIR) light developed for in vivo molecular targeting and reporting of cancer provides promising opportunities for diagnostic imaging. The current state of the art of NIR fluorescence-enhanced optical tomography is reviewed in the context of the principle of fluorescence, the different measurement schemes employed, and the mathematical tools established to tomographically reconstruct the fluorescence optical properties in various tissue domains. Finally, we discuss the recent advances in forward modeling and distributed memory parallel computation to provide robust, accurate, and fast fluorescence-enhanced optical tomography.