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BioMed Research International
Volume 2016, Article ID 5140823, 8 pages
Review Article

Neuronal Changes in the Diabetic Cornea: Perspectives for Neuroprotection

Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba, Chiba 260-8670, Japan

Received 23 August 2016; Revised 14 October 2016; Accepted 23 October 2016

Academic Editor: Nick Di Girolamo

Copyright © 2016 Guzel Bikbova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Diabetic neuropathy is associated with neurotrophic ulcerations of the skin and cornea. Decreased corneal sensitivity and impaired innervation lead to weakened epithelial wound healing predisposing patients to ocular complications such as corneal infections, stromal opacification, and surface irregularity. This review presents recent findings on impaired corneal innervation in diabetic individuals, and the findings suggest that corneal neuropathy might be an early indicator of diabetic neuropathy. Additionally, the recent findings for neuroprotective and regenerative therapy for diabetic keratopathy are presented.