L-Malate’s Plasma and Excretion Profile in the Treatment of Moderate and Severe Hemorrhagic Shock in Rats

Figure 5

Effects of RS, MR7, MR13.6, and MR21 on the urinary concentrations (a) and absolute amounts (b) of citrate. Rats underwent moderate hemorrhagic shock, were resuscitated with RS, MR7, MR13.6, or MR21, respectively, and were observed until the end of experiment. Urinary samples were collected immediately after catheter insertion and before shock induction ( = 0–30 min) and during shock induction ( = 30–60 min), resuscitation ( = 120–150 min), and the last third of the observation period ( = 240–300 min). The values plotted are mean ± SEM of 6 individual experiments. , , , or compared with the RS-control group.

(a)

(b)