In Vitro Growth Inhibitory Activities of Natural Products from Irciniid Sponges against Cancer Cells: A Comparative Study

Table 2

GI₅₀ (M) values for compounds 1–6 against human and murine cancer cell lines.

Compound	Human					Murine	Mean ± SEM
	A549	Hs683	MCF-7	SKMEL-28	U373	B16F10
1	>100	94	67	>100	>100	73	>89
2	>100	>100	>100	>100	>100	66	>94
3	>100	>100	>100	>100	>100	77	>96
4	23	27	3	3	15	1	12 ± 5
5	34	45	5	4	48	4	23 ± 9
6	4	5	4	1	5	1	3 ± 1

GI₅₀: in vitro concentration (M) needed to inhibit cell population growth by 50% after 72 hours of cell culture with the compound.