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BioMed Research International
Volume 2016, Article ID 5420345, 6 pages
Clinical Study

Association between Serum Ferritin and Contrast-Induced Nephropathy in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

1Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China
2Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
3Department of Cardiology, Xishan People’s Hospital, Wuxi Branch of Zhongda Hospital, Wuxi 214000, China

Received 1 February 2016; Accepted 11 July 2016

Academic Editor: Giuseppe M. Sangiorgi

Copyright © 2016 Boqian Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Aims. CIN is a major and serious complication following PCI in patients with ACS. It is unclear whether a higher serum ferritin level is associated with an increased risk of CIN in high-risk patients. Thus, we conducted this study to assess the predictive value of SF for the risk of CIN after PCI. Methods. We prospectively examined SF levels in 548 patients with ACS before undergoing PCI. Multivariate logistic regression analysis was used to analyze the independent risk factors for CIN. The ROC analysis was performed to evaluate the predictive value of SF for CIN. Results. CIN occurred in 96 patients. Baseline SF was higher in patients who developed CIN compared to those who did not ( versus ; ). Multivariate logistic regression analysis showed that SF was an independent predictor of CIN (OR, 1.008; 95% CI, 1.003–1.013; ). The area under ROC curve for SF was 0.629, and SF > 180.9 μg/L predicted CIN with sensitivity of 80.2% and specificity of 41.4%. Conclusion. Our data show that a higher SF level was significantly associated with an increased risk of CIN after PCI.