Update on Mechanisms of Renal Tubule Injury Caused by Advanced Glycation End Products

Figure 3

Effects of CML, anti-RAGE antibody, and an ERS inhibitor on the intracellular cholesterol content of HK-2 cells. Oil Red O staining (a) and intracellular cholesterol ester (b) were examined after incubation with CML, CML plus anti-RAGE antibody, CML plus 4-PBA, or 4-PBA alone for 24 h. The histogram represents the means ± SD of the intracellular cholesterol ester content from 3 experiments, expressed as a percentage of Ctr. , compared with the Ctr; , compared with CML.

(a)

(b)