Research Article

Distribution of Triamcinolone Acetonide after Intravitreal Injection into Silicone Oil-Filled Eye

Figure 4

Representative T2-weighted images of vitrectomized pig eyes before and after drug injection. High-resolution T2-weighted images were taken immediately before drug injection (before injection) and 5 minutes after the completion of dynamic T1-weighted MRI scan (after injection). The scanning parameter was adjusted in order to reduce the chemical shift artifact (CSA) while maintaining the signal to noise ratio (SNR) level. The TA drug droplet was well represented in the postinjection images, which indicated that the drug droplets could sink and stay inside Siluron 2000 silicone oil bubble for up to 16 minutes after the injection. The trail of TA suspension in the postinjection image indicated the small position change of the droplet during the 5 minutes scanning time for the T2-weighted image.