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BioMed Research International
Volume 2016 (2016), Article ID 5631935, 7 pages
http://dx.doi.org/10.1155/2016/5631935
Research Article

Expression of HIF-2α and VEGF in Cervical Squamous Cell Carcinoma and Its Clinical Significance

1Jiaxing Maternity and Child Health Care Hospital, Jianxin 314050, China
2Department of Physiology, Basic Medical College, Nanchang University, Nanchang 330006, China
3The First Clinical Medical College, Nanchang University, Nanchang 330006, China
4The Second Clinical Medical College, Nanchang University, Nanchang 330006, China

Received 19 February 2016; Accepted 26 May 2016

Academic Editor: Mi-Yeon Jung

Copyright © 2016 Lixia Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

CSCC is a systemic disease involving polygenic alteration and multiple steps, and HIF and VEGF are closely associated with tumorigenesis. Specimens surgically resected from 64 cases of CSCC and 22 cases of normal cervical tissue were selected randomly to detect the expression of HIF-2α and VEGF in CSCC for exploring their clinical significance; information regarding the age, lymph node metastasis, and FIGO staging were collected as well; expression of HIF-2α and VEGF was detected by qPCR and immunohistochemistry. We found that the expression of HIF-2α and VEGF mRNA in CSCC was significantly higher than that of normal cervical tissues and showed a positive correlation between them. The positive rates of HIF-2α and VEGF protein expression in CSCC and normal cervical tissues were 93.8% and 18.2%, respectively, with correlation between them. The expression of both HIF-2α and VEGF mRNA did not relate closely to age but the FIGO staging and lymph node metastasis. Compared with the counterpart control group, CSCC tissues with high FIGO staging and lymph node metastasis had a higher level of HIF-2α and VEGF mRNA expression. So, HIF-2α and VEGF were overexpressed in CSCC, which has a great clinical significance for its diagnosis.