BioMed Research International / 2016 / Article / Tab 3 / Research Article
Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis Table 3 Multivariate analyses predicting probability of cancer recurrence in relation to the neutrophil-to-lymphocyte ratio in patients with nonmetastatic renal cell carcinoma.
Variables NLR as a continuous variable NLR as a categorical variable HR 95% CI valueHR 95% CI valueAge 1.011 0.997–1.025 0.134 1.011 0.997–1.026 0.123 Gender Female versus male 0.873 0.588–1.296 0.502 0.876 0.591–1.299 0.510 BMI 0.959 0.907–1.015 0.146 0.959 0.907–1.014 0.146 ECOG PS ≥1 versus 0 1.936 1.270–2.950 0.002 1.900 1.244–2.902 0.003 Symptoms at presentation 1.185 0.811–1.731 0.380 1.208 0.830–1.758 0.325 Tumor size 1.011 1.005–1.017 0.001 1.011 1.004–1.017 0.001 T stage 0.009 0.010 T2 versus T1 1.384 0.745–2.571 0.303 1.376 0.743–2.550 0.310 T3-4 versus T1 2.068 1.281–3.340 0.003 2.050 1.267–3.314 0.003 Fuhrman’s grade G3-4 versus G1-2 1.974 1.352–2.882 <0.001 1.958 1.340–2.863 0.001 Histologic subtype 0.012 0.019 pRCC versus cRCC 1.044 0.582–1.872 0.886 1.029 0.575–1.841 0.924 chRCC versus cRCC 0.104 0.023–0.467 0.003 0.132 0.032–0.545 0.005 Sarcomatoid differentiation 2.095 1.061–4.137 0.033 2.004 1.010–3.977 0.047 Tumor necrosis 1.255 0.817–1.927 0.300 1.265 0.825–1.939 0.282 NLR (1) Continuous 1.081 1.009–1.160 0.028 (2) High versus low NLR 1.788 1.153–2.771 0.009
NLR, neutrophil-to-lymphocyte ratio; low NLR, <3.7; high NLR, ≥3.7; BMI, body mass index; ECOG PS, Eastern Cooperative Oncology Group performance status; cRCC, clear cell renal cell carcinoma; pRCC, papillary renal cell carcinoma; chRCC, chromophobe renal cell carcinoma; HR, hazard ratio; CI, confidence interval.