Research Article

Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis

Table 3

Multivariate analyses predicting probability of cancer recurrence in relation to the neutrophil-to-lymphocyte ratio in patients with nonmetastatic renal cell carcinoma.

VariablesNLR as a continuous variableNLR as a categorical variable
HR95% CI valueHR95% CI value

Age1.0110.997–1.0250.1341.0110.997–1.0260.123
Gender
 Female versus male0.8730.588–1.2960.5020.8760.591–1.2990.510
BMI0.9590.907–1.0150.1460.9590.907–1.0140.146
ECOG PS
 ≥1 versus 01.9361.270–2.9500.0021.9001.244–2.9020.003
Symptoms at presentation1.1850.811–1.7310.3801.2080.830–1.7580.325
Tumor size1.0111.005–1.0170.0011.0111.004–1.0170.001
T stage0.0090.010
 T2 versus T11.3840.745–2.5710.3031.3760.743–2.5500.310
 T3-4 versus T12.0681.281–3.3400.0032.0501.267–3.3140.003
Fuhrman’s grade
 G3-4 versus G1-21.9741.352–2.882<0.0011.9581.340–2.8630.001
Histologic subtype0.0120.019
 pRCC versus cRCC1.0440.582–1.8720.8861.0290.575–1.8410.924
 chRCC versus cRCC0.1040.023–0.4670.0030.1320.032–0.5450.005
Sarcomatoid differentiation2.0951.061–4.1370.0332.0041.010–3.9770.047
Tumor necrosis1.2550.817–1.9270.3001.2650.825–1.9390.282
NLR
 (1) Continuous1.0811.009–1.1600.028
 (2) High versus low NLR1.7881.153–2.7710.009

NLR, neutrophil-to-lymphocyte ratio; low NLR, <3.7; high NLR, ≥3.7; BMI, body mass index; ECOG PS, Eastern Cooperative Oncology Group performance status; cRCC, clear cell renal cell carcinoma; pRCC, papillary renal cell carcinoma; chRCC, chromophobe renal cell carcinoma; HR, hazard ratio; CI, confidence interval.