The Epithelial Sodium Channel and the Processes of Wound Healing

Figure 1

Scheme of the basic mechanisms of ENaC regulation. The scheme indicates the effects of several modulators on the channel activity and/or expression. The three levels of regulation of ENaC are integrated in the scheme: (i) modulation of the kinetic properties of the channel in situ at the plasma membrane or at its trafficking, (ii) regulation of its synthesis and retrieval from the plasma membrane, and (iii) the effects of first and second messengers on the signaling networks that modulate the channel’s activity, with emphasis on aldosterone. MT: methyltransferases. See the main text for a detailed description of the regulatory effects.