Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet Function
Table 1
Summary of GPIIb (ITGA2B) variations detected in this study.
Sequence number obtained in this study
dbSNP
Location
NC_000017.11
NM_000419.3
Nucleotide change
NP_000410.2 amino acid change
MA(F)
H-W
ITGA2B-01
rs3760364
5′ upstream end
44390436
-963
ctcccaaggg A/T ctcatttaca
T(0.052)
0.609
ITGA2B-02
New
5′ upstream end
44390152
-679
tagaccaagg T/C ccattcacca
C(0.006)
0.957
ITGA2B-03
New
5′ upstream end
44390081
-608
caagacggag G/A aggagtgagg
A(0.006)
0.957
ITGA2B-04
New
Exon3
44385910
354
tgatgagacc C/T gaaatgtagg
Arg108Stop
T(0.006)
0.957
ITGA2B-05
New
Exon13
44380960
1344
ctcccaggtc C/A tggacagccc
Leu438Met
A(0.006)
0.957
ITGA2B-06
rs201355504
Intron13
44380821
1393+58
cttggcactt C/T cagcgaatgt
A(0.006)
0.957
ITGA2B-07
New
Exon14
44380638
1401
tagacctgat C/G gtgggagctt
Ile467Met
G(0.006)
0.957
ITGA2B-08
rs850730
Intron21
44377095
2188-7C>G
ccctcctcat C/G tcccagatag
G(0.477)
0.289
ITGA2B-09
New
Exon23
44376336
2320
cgtgccggtc C/T gggcagaggc
Arg774Trp
T(0.006)
0.957
ITGA2B-10
rs117870452
Exon23
44376322
2334
gcagctccac C/T tgggcctctg
Gln778=
G(0.012)
0.913
ITGA2B-11
rs5911
Exon26
44375697
2621T>G
ggggctgggg A/C tgggcagccc
Ile874Ser
G(0.477)
0.289
ITGA2B-12
rs5910
Exon30
44372421
3063C>T
acccccaggt C/T ggcttcttca
Val1021=
T(0.465)
0.289
ITGA2B-13
New
3′-UTR
44372213
151C>A
gctacccccc C/A tcctgctgcc
A(0.017)
0.869
dbSNP, single nucleotide polymorphism database; H-W , Hardy–Weinberg equilibrium value; MA(F), minor allele (frequency); GP, glycoprotein. SNPs which related with bleeding time in this study.