Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet Function

Table 5

Association between individual ITGA2B and ITGB3 SNPs and the coagulation indexes (mean ± SD).

	Genotypes		PT (s)	APTT (s)	TT (s)	FIB (g/L)
	CC	42
	CT	12
	TT	1	12.5	36.7	16.5	2.72
			0.126	0.029	0.299	0.173
	AA	27
	AG	21
	GG	7
			0.770	0.088	0.015	0.029
rs70940817	GG	45
	GA	9
	AA	1	12.7	37.2	15.75	3.10
			0.002	0.003	0.078	0.069

MPV, mean platelet volume; PLT, platelet count; PT, prothrombin time; APTT, activated partial thromboplastin time; FIB, fibrinogen; TT, thrombin time.
Note: Pearson’s two-tailed test was used to analyze correlation between genotype and parameter.
Strong LD was observed between rs112188890 and rs117414137 (); completely LD was observed between rs4642 and rs4634.