Efficacy of Scutellaria baicalensis for the Treatment of Hand, Foot, and Mouth Disease Associated with Encephalitis in Patients Infected with EV71: A Multicenter, Retrospective Analysis
Table 1
Demographic and clinical characteristics of cases.
Variable
Scutellaria baicalensis group
Ribavirin group
/-test ( value)
Sex
Male
238 (57.8)
193 (61.7)
1.1190 (0.2901)
Female
174 (42.2)
120 (38.3)
Age (months)
1.5479 (0.1221)
Location of residence
Urban
220 (53.4)
178 (56.7)
0.8655 (0.3522)
Rural
192 (46.6)
135 (43.3)
Medication use before hospitalization
Yes
274 (66.5)
200 (63.9)
0.5341 (0.4649)
No
138 (33.5)
113 (36.1)
Previous history of HFMD
Yes
56 (13.6)
36 (11.5)
0.4207 (0.5166)
No
356 (86.4)
277 (88.5)
0.7017 (0.4022)
Symptoms
Fever
412 (100.0)
313 (100.0)
— (1.0000)
Skin rash
412 (100.0)
313 (100.0)
— (1.0000)
Oral lesion
412 (100.0)
313 (100.0)
— (1.0000)
NS involvement
412 (100.0)
313 (100.0)
— (1.0000)
FBG level (mmol/L)
1.1656 (0.2442)
PWBC count (×109/L)
0.9263 (0.3546)
CSF-WBC count (×106/L)
0.9709 (0.3319)
EEG abnormality
262 (63.6)
196 (62.6)
0.0723 (0.7880)
MRI abnormality
112 (27.2)
89 (28.4)
0.1387 (0.7096)
A total of 725 patients with HFMD were enrolled in the present study, including 412 patients in the Scutellaria baicalensis group and 313 in the ribavirin group. Data are presented as (%) or the mean ± standard deviation. HFMD: hand, foot, and mouth disease; NS: nervous system; FBG: fasting blood glucose; PWBC: peripheral white blood cells; CSF: cerebrospinal fluid; EEG: electroencephalograph; MRI: magnetic resonance imaging. The data for the clinical manifestations were compared using Fisher’s exact test.
